FOLR2 binds FOLA

Stable Identifier
R-HSA-8940134
Type
Reaction [binding]
Species
Homo sapiens
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The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). Antifolates are folate analogues that inhibit vitamin B9 (folic acid)-using cellular enzymes are used in the treatment of cancer and inflammatory diseases. Targeting FOLR2 may be a way to investigate novel folate-based drugs in the treatment of these diseases (Wibowo et al. 2013).

Literature References
PubMed ID Title Journal Year
4066659 Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells

Antony, AC, Kane, MA, Portillo, RM, Elwood, PC, Kolhouse, JF

J. Biol. Chem. 1985
2605182 Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

Ratnam, M, Marquardt, H, Duhring, JL, Freisheim, JH

Biochemistry 1989
23934049 Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition

Wibowo, AS, Singh, M, Reeder, KM, Carter, JJ, Kovach, AR, Meng, W, Ratnam, M, Zhang, F, Dann, CE

Proc. Natl. Acad. Sci. U.S.A. 2013
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