Reactome | FOLR2 binds FOLA

FOLR2 binds FOLA

Stable Identifier

R-HSA-8940134

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The folate receptor beta (FOLR2, FBP) (Ratnam et al. 1989) binds folate (FOLA) and reduced folic acid derivatives and mediates their delivery into cells (Antony et al. 1985). Antifolates are folate analogues that inhibit vitamin B9 (folic acid)-using cellular enzymes are used in the treatment of cancer and inflammatory diseases. Targeting FOLR2 may be a way to investigate novel folate-based drugs in the treatment of these diseases (Wibowo et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
2605182	Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA Ratnam, M, Marquardt, H, Duhring, JL, Freisheim, JH	Biochemistry	1989
4066659	Studies of the role of a particulate folate-binding protein in the uptake of 5-methyltetrahydrofolate by cultured human KB cells Antony, AC, Kane, MA, Portillo, RM, Elwood, PC, Kolhouse, JF	J. Biol. Chem.	1985
23934049	Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition Wibowo, AS, Singh, M, Reeder, KM, Carter, JJ, Kovach, AR, Meng, W, Ratnam, M, Zhang, F, Dann, CE	Proc. Natl. Acad. Sci. U.S.A.	2013