Reactome | SLC25A32 transports THF from cytosol to mitochondrial matrix

SLC25A32 transports THF from cytosol to mitochondrial matrix

Stable Identifier

R-HSA-200680

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Cytosolic tetrahydrofolate import across the inner mitochondrial membrane

ReviewStatus

5/5

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SLC25A32 transports THF from cytosol to mitochondrial matrix

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SLC25A32 protein in the inner mitochondrial membrane mediates the reversible transport of tetrahydrofolate between the cytosol and the mitochondrial matrix. Retention of tetrahydrofolate within the mitochondrial matrix is dependent on mitochondrial polyglutamate addition (Titus and Moran 2000; Chen et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Korenberg, J, Shane, B, Qi, H, Garrow, TA, Choi, YJ, Chen, L	J Biol Chem	1996
10978331	Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. Moran, RG, Titus, SA	J Biol Chem	2000

Participants

Input

THF [cytosol]

Output

THF [mitochondrial matrix]

Participates

as an event of

Metabolism of folate and pterines (Homo sapiens)

Event Information

Reverse Reaction

SLC25A32 transports THF from mitochondrial matrix to cytosol (Homo sapiens)

Catalyst Activity

folic acid transmembrane transporter activity of SLC25A32 [mitochondrial inner membrane]

Physical Entity

SLC25A32 [mitochondrial inner membrane] (Homo sapiens)

Activity

folic acid transmembrane transporter activity (GO:0008517)

Orthologous Events

SLC25A32 transports THF from cytosol to mitochondrial matrix (Bos taurus)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Caenorhabditis elegans)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Canis familiaris)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Danio rerio)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Dictyostelium discoideum)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Drosophila melanogaster)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Gallus gallus)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Mus musculus)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Plasmodium falciparum)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Rattus norvegicus)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Saccharomyces cerevisiae)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Schizosaccharomyces pombe)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Sus scrofa)

SLC25A32 transports THF from cytosol to mitochondrial matrix (Xenopus tropicalis)

Created

D'Eustachio, P (2007-07-24)

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