Reactome | PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

Stable Identifier

R-HSA-5694137

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser

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Mitochondrial serine hydroxymethyltransferase (SHMT2) contributes to the de novo mitochondrial thymidylate biosynthesis pathway which is essential for mitochondrial DNA (mtDNA) integrity. It is associated with the inner mitochondrial membrane and is functional as a homotetramer. SHMT2 transfers a hydroxymethyl group from 5,10-methylenetetrahydrofolate (5,10MTHF) to glycine (Gly), forming tetrahydrofolate (THF) and L-serine (L-Ser) (Anderson et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21876188	Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria Anderson, DD, Quintero, CM, Stover, PJ	Proc. Natl. Acad. Sci. U.S.A.	2011