MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

Stable Identifier
R-HSA-200718
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+
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The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate, NADPH, and H+ to form 5,10-methyleneTHF polyglutamate and NADP+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Participants
Participates
Event Information
Catalyst Activity

methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity of MTHFD1 dimer [cytosol]

Orthologous Events
Created
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