Reactome | SLC46A1 transports FOLA from extracellular region to cytosol

SLC46A1 transports FOLA from extracellular region to cytosol

Stable Identifier

R-HSA-200729

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular folate import across the plasma membrane

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SLC46A1 transports FOLA from extracellular region to cytosol

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SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition. Although the SLC46A1 gene is expressed in several tissues in the body, this transporter appears to be primarily needed for absorption of dietary folate from the intestinal lumen (Qiu et al. 2006; Chen et al. 1996).

Literature References

PubMed ID	Title	Journal	Year
17129779	Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Jansen, M, Sandoval, C, Akabas, MH, Goldman, ID, Sakaris, A, Tsai, E, Zhao, R, Chattopadhyay, S, Min, SH, Qiu, A	Cell	2006
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Korenberg, J, Shane, B, Qi, H, Garrow, TA, Choi, YJ, Chen, L	J Biol Chem	1996