Reactome | SLC46A1 transports FOLA from extracellular region to cytosol

SLC46A1 transports FOLA from extracellular region to cytosol

Stable Identifier

R-HSA-200729

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Extracellular folate import across the plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

SLC46A1 transports FOLA from extracellular region to cytosol

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition. The SLC46A1 gene is expressed in several tissues in the body, and is needed for absorption of dietary folate from the intestinal lumen (Chen et al. 1996; Qiu et al. 2006; Umpathy et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17129779	Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption Qiu, A, Jansen, M, Sakaris, A, Min, SH, Chattopadhyay, S, Tsai, E, Sandoval, C, Zhao, R, Akabas, MH, Goldman, ID	Cell	2006
17962486	Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types Umapathy, NS, Gnana-Prakasam, JP, Martin, PM, Mysona, B, Dun, Y, Smith, SB, Ganapathy, V, Prasad, PD	Invest Ophthalmol Vis Sci	2007
8662720	Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene Chen, L, Qi, H, Korenberg, J, Garrow, TA, Choi, YJ, Shane, B	J Biol Chem	1996