Extracellular folate import across the plasma membrane

Stable Identifier
R-HSA-200729
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
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Extracellular folate import across the plasma membrane
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SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition. Although the SLC46A1 gene is expressed in several tissues in the body, this transporter appears to be primarily needed for absorption of dietary folate from the intestinal lumen (Qiu et al. 2006; Chen et al. 1996).

Literature References
PubMed ID Title Journal Year
8662720 Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

Chen, L, Qi, H, Korenberg, J, Garrow, TA, Choi, YJ, Shane, B

J Biol Chem 1996
17129779 Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

Qiu, A, Jansen, M, Sakaris, A, Min, SH, Chattopadhyay, S, Tsai, E, Sandoval, C, Zhao, R, Akabas, MH, Goldman, ID

Cell 2006
Participants
Input
Output
Participant Of
hasEvent
Event Information
Reverse Reaction
Cytosolic folate export across the plasma membrane (Homo sapiens)
Catalyst Activity
Catalyst Activity
Title
folic acid transmembrane transporter activity of SLC46A1 [plasma membrane]
Physical Entity
SLC46A1 [plasma membrane]
Activity
folic acid transmembrane transporter activity (0008517)
Orthologous Events
Extracellular folate import across the plasma membrane (Bos taurus)
Extracellular folate import across the plasma membrane (Caenorhabditis elegans)
Extracellular folate import across the plasma membrane (Canis familiaris)
Extracellular folate import across the plasma membrane (Danio rerio)
Extracellular folate import across the plasma membrane (Drosophila melanogaster)
Extracellular folate import across the plasma membrane (Gallus gallus)
Extracellular folate import across the plasma membrane (Mus musculus)
Extracellular folate import across the plasma membrane (Rattus norvegicus)
Extracellular folate import across the plasma membrane (Saccharomyces cerevisiae)
Extracellular folate import across the plasma membrane (Schizosaccharomyces pombe)
Extracellular folate import across the plasma membrane (Sus scrofa)
Extracellular folate import across the plasma membrane (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)