5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

Stable Identifier
R-HSA-200740
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate
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The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate and H2O to form 10-formylTHF polyglutamate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).
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Event Information
Reverse Reaction
MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG (Homo sapiens)
Catalyst Activity

methenyltetrahydrofolate cyclohydrolase activity of MTHFD1 dimer [cytosol]

Physical Entity
MTHFD1 dimer [cytosol] (Homo sapiens)
Activity
methenyltetrahydrofolate cyclohydrolase activity (GO:0004477)
Orthologous Events
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Bos taurus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Caenorhabditis elegans)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Canis familiaris)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Danio rerio)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Dictyostelium discoideum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Drosophila melanogaster)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Gallus gallus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Mus musculus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Plasmodium falciparum)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Rattus norvegicus)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Saccharomyces cerevisiae)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Schizosaccharomyces pombe)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Sus scrofa)
5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate (Xenopus tropicalis)
Created
D'Eustachio, P  (2007-07-24)
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