SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG

Stable Identifier
R-HSA-200735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine
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Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of tetrahydrofolate polyglutamate (THF polyglutamate) and serine to form 5,10-methyleneTHF polyglutamate and glycine. The active form of the enzyme is a tetramer (Renwick et al. 1998). In the body, this reaction is a major source of 5,10-methyleneTHF, which in turn is a critical precursor in the synthesis of dTMP.

Literature References
PubMed ID Title Journal Year
9753690 The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy

Renwick, SB, Snell, K, Baumann, U

Structure 1998
Participants
Participates
Event Information
Catalyst Activity

glycine hydroxymethyltransferase activity of SHMT1 tetramer [cytosol]

Orthologous Events
Created
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