DHF is reduced to tetrahydrofolate (THF)

Stable Identifier
R-HSA-197972
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic dihydrofolate reductase catalyzes the reaction of dihydrofolate, NADPH, and H+ to form tetrahydrofolate (THF) and NADP+ (Chen et al. 1984; Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Freisheim, JH, Kraut, J, Prendergast, NJ, Delcamp, TJ, Ashford, VA, Davies JF, 2nd

Biochemistry 1990
6323448 The functional human dihydrofolate reductase gene

Cline, A, Humphries, RK, Maizel, J, Moulton, AD, Chen, MJ, Shimada, T, Nienhuis, AW

J Biol Chem 1984
Participants
Participates
Catalyst Activity

folate reductase activity of DHFR2 [cytosol]

Orthologous Events
Cross References
Rhea
Created
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