Cytosolic dihydrofolate reductase catalyzes the reaction of folate, NADPH, and H+ to form dihydrofolate and NADP+ (Chen et al. 1984; Davies et al. 1990).
Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW
Davies JF, 2nd, Delcamp, TJ, Prendergast, NJ, Ashford, VA, Freisheim, JH, Kraut, J
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