DHFR2 reduces FOLA to DHF

Stable Identifier
R-HSA-197963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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DHFR2 reduces FOLA to DHF
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Dihydrofolate reductase 2 (DHFR2) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984).
Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW

J Biol Chem 1984
Participants
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Output
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as an event of
Catalyst Activity

folate reductase activity of DHFR2 [cytosol]

Physical Entity
DHFR2 [cytosol] (Homo sapiens)
Activity
folate reductase activity (GO:0033560)
Orthologous Events
DHFR2 reduces FOLA to DHF (Bos taurus)
DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
DHFR2 reduces FOLA to DHF (Canis familiaris)
DHFR2 reduces FOLA to DHF (Danio rerio)
DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)
DHFR2 reduces FOLA to DHF (Drosophila melanogaster)
DHFR2 reduces FOLA to DHF (Gallus gallus)
DHFR2 reduces FOLA to DHF (Mus musculus)
DHFR2 reduces FOLA to DHF (Rattus norvegicus)
DHFR2 reduces FOLA to DHF (Saccharomyces cerevisiae)
DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)
DHFR2 reduces FOLA to DHF (Sus scrofa)
Cross References
RHEA
Authored
Jassal, B  (2007-05-16)
Created
Jassal, B  (2007-05-16)
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