DHFR2 reduces FOLA to DHF

Stable Identifier
R-HSA-197963
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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DHFR2 reduces FOLA to DHF
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Dihydrofolate reductase 2 (DHFR2) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984).

Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Cline, A, Humphries, RK, Maizel, J, Moulton, AD, Chen, MJ, Shimada, T, Nienhuis, AW

J Biol Chem 1984
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Output
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as an event of
Catalyst Activity

folate reductase activity of DHFR2 [cytosol]

Physical Entity
DHFR2 [cytosol] (Homo sapiens)
Activity
folate reductase activity (GO:0033560)
Orthologous Events
DHFR2 reduces FOLA to DHF (Bos taurus)
DHFR2 reduces FOLA to DHF (Caenorhabditis elegans)
DHFR2 reduces FOLA to DHF (Canis familiaris)
DHFR2 reduces FOLA to DHF (Danio rerio)
DHFR2 reduces FOLA to DHF (Dictyostelium discoideum)
DHFR2 reduces FOLA to DHF (Drosophila melanogaster)
DHFR2 reduces FOLA to DHF (Mus musculus)
DHFR2 reduces FOLA to DHF (Rattus norvegicus)
DHFR2 reduces FOLA to DHF (Schizosaccharomyces pombe)
DHFR2 reduces FOLA to DHF (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-05-16)
Created
Jassal, B  (2007-05-16)
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