Folate is reduced to dihydrofolate (DHF)

Stable Identifier
R-HSA-197963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Folate is reduced to dihydrofolate (DHF)
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Cytosolic dihydrofolate reductase catalyzes the reaction of folate, NADPH, and H+ to form dihydrofolate and NADP+ (Chen et al. 1984; Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW

J Biol Chem 1984
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Davies JF, 2nd, Delcamp, TJ, Prendergast, NJ, Ashford, VA, Freisheim, JH, Kraut, J

Biochemistry 1990
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
folate reductase activity of DHFR [cytosol]
Physical Entity
DHFR [cytosol]
Activity
folate reductase activity (0033560)
Orthologous Events
Folate is reduced to dihydrofolate (DHF) (Bos taurus)
Folate is reduced to dihydrofolate (DHF) (Caenorhabditis elegans)
Folate is reduced to dihydrofolate (DHF) (Canis familiaris)
Folate is reduced to dihydrofolate (DHF) (Danio rerio)
Folate is reduced to dihydrofolate (DHF) (Dictyostelium discoideum)
Folate is reduced to dihydrofolate (DHF) (Drosophila melanogaster)
Folate is reduced to dihydrofolate (DHF) (Mus musculus)
Folate is reduced to dihydrofolate (DHF) (Rattus norvegicus)
Folate is reduced to dihydrofolate (DHF) (Schizosaccharomyces pombe)
Folate is reduced to dihydrofolate (DHF) (Sus scrofa)
Folate is reduced to dihydrofolate (DHF) (Xenopus tropicalis)
Cross References
Rhea
Created
Jassal, B  (2007-05-16)