DHFR dimer reduces FOLA to DHF

Stable Identifier
R-HSA-9709098
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cytosolic, dimeric dihydrofolate reductase (DHFR dimer) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984). Crystal structures of DHFR bound to its substrate folate reveal it functions as a homodimer (Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW

J Biol Chem 1984
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Davies JF, 2nd, Delcamp, TJ, Prendergast, NJ, Ashford, VA, Freisheim, JH, Kraut, J

Biochemistry 1990
Participants
Participates
Catalyst Activity

folate reductase activity of DHFR dimer [cytosol]

Orthologous Events
Authored
Created
Cite Us!