DHFR dimer reduces FOLA to DHF

Stable Identifier
R-HSA-9709098
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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DHFR dimer reduces FOLA to DHF
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Cytosolic, dimeric dihydrofolate reductase (DHFR dimer) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984). Crystal structures of DHFR bound to its substrate folate reveal it functions as a homodimer (Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Freisheim, JH, Kraut, J, Prendergast, NJ, Delcamp, TJ, Ashford, VA, Davies JF, 2nd

Biochemistry 1990
6323448 The functional human dihydrofolate reductase gene

Cline, A, Humphries, RK, Maizel, J, Moulton, AD, Chen, MJ, Shimada, T, Nienhuis, AW

J Biol Chem 1984
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Catalyst Activity

folate reductase activity of DHFR dimer [cytosol]

Physical Entity
DHFR dimer [cytosol] (Homo sapiens)
Activity
folate reductase activity (GO:0033560)
Orthologous Events
DHFR dimer reduces FOLA to DHF (Bos taurus)
DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
DHFR dimer reduces FOLA to DHF (Canis familiaris)
DHFR dimer reduces FOLA to DHF (Danio rerio)
DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)
DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)
DHFR dimer reduces FOLA to DHF (Mus musculus)
DHFR dimer reduces FOLA to DHF (Rattus norvegicus)
DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)
DHFR dimer reduces FOLA to DHF (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-05-16)
Created
Jassal, B  (2020-12-10)
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