DHFR dimer reduces FOLA to DHF

Stable Identifier
R-HSA-9709098
Type
Reaction
Species
Homo sapiens
Compartment
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Cytosolic, dimeric dihydrofolate reductase (DHFR dimer) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984). Crystal structures of DHFR bound to its substrate folate reveal it functions as a homodimer (Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Freisheim, JH, Kraut, J, Prendergast, NJ, Delcamp, TJ, Ashford, VA, Davies JF, 2nd

Biochemistry 1990
6323448 The functional human dihydrofolate reductase gene

Cline, A, Humphries, RK, Maizel, J, Moulton, AD, Chen, MJ, Shimada, T, Nienhuis, AW

J Biol Chem 1984
Participants
Participates
Catalyst Activity

folate reductase activity of DHFR dimer [cytosol]

Orthologous Events
Cross References
Rhea
Authored
Created
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