DHFR dimer reduces FOLA to DHF

Stable Identifier
R-HSA-9709098
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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DHFR dimer reduces FOLA to DHF
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Cytosolic, dimeric dihydrofolate reductase (DHFR dimer) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984). Crystal structures of DHFR bound to its substrate folate reveal it functions as a homodimer (Davies et al. 1990).

Literature References
PubMed ID Title Journal Year
6323448 The functional human dihydrofolate reductase gene

Chen, MJ, Shimada, T, Moulton, AD, Cline, A, Humphries, RK, Maizel, J, Nienhuis, AW

J Biol Chem 1984
2248959 Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate

Davies JF, 2nd, Delcamp, TJ, Prendergast, NJ, Ashford, VA, Freisheim, JH, Kraut, J

Biochemistry 1990
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as an event of
Catalyst Activity

folate reductase activity of DHFR dimer [cytosol]

Physical Entity
DHFR dimer [cytosol] (Homo sapiens)
Activity
folate reductase activity (GO:0033560)
Orthologous Events
DHFR dimer reduces FOLA to DHF (Bos taurus)
DHFR dimer reduces FOLA to DHF (Caenorhabditis elegans)
DHFR dimer reduces FOLA to DHF (Canis familiaris)
DHFR dimer reduces FOLA to DHF (Danio rerio)
DHFR dimer reduces FOLA to DHF (Dictyostelium discoideum)
DHFR dimer reduces FOLA to DHF (Drosophila melanogaster)
DHFR dimer reduces FOLA to DHF (Mus musculus)
DHFR dimer reduces FOLA to DHF (Rattus norvegicus)
DHFR dimer reduces FOLA to DHF (Schizosaccharomyces pombe)
Authored
Jassal, B  (2007-05-16)
Created
Jassal, B  (2020-12-10)
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