Reactome | Psmd7 [nucleoplasm]

Psmd7 [nucleoplasm]

Stable Identifier

R-MMU-174309

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

PSMD7, P26516

Locations in the PathwayBrowser

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Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)

DNA Replication (Mus musculus)

- DNA Replication Pre-Initiation (Mus musculus)
  - Assembly of the pre-replicative complex (Mus musculus)
    - Ubiquitinated geminin is degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)

Signal Transduction (Mus musculus)

- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'on' state (Mus musculus)
    - GLI2,3 are degraded by the proteasome (Mus musculus)
      - 26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP lid [nucleoplasm] (Mus musculus)
        
        19S RP lid particle 2 [nucleoplasm] (Mus musculus)
        
        19S RP Lid Module 1 [nucleoplasm] (Mus musculus)
        
        PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)
        
        Psmd7 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P26516 Psmd7

Gene Names

Psmd7, Mov-34, Mov34

Chain

chain:1-321

Reference Genes

BioGPS Gene:17463 Psmd7

KEGG:mmu:17463 Psmd7

Monarch:17463 Psmd7

NCBI Gene:17463 Psmd7

UCSC:P26516 Psmd7

Reference Transcript

RefSeq:NM_010817.2 Psmd7

Other Identifiers

103350_at

10581560

1432820_at

1451056_at

17463

17512755

4437408

4502702

4542107

4752040

4911394

5022109

5041125

5135129

5171260

5172515

5363977

5376967

5436780

5499986

5558214

5595800

5603802

A_51_P487933

A_52_P171993

A_52_P676913

A_55_P2935710

GE35753

GO:0000502

GO:0005515

GO:0005838

GO:0008233

GO:0008237

GO:0030163

GO:0042803

GO:0043161

ILMN_1220284

ILMN_1253915

ILMN_2630438

m64640_s_at

mMC010425

Participates

as a component of

PSMD7:PSMD12:PSMD13:PSMD14 [nucleoplasm] (Mus musculus)

Other forms of this molecule

Psmd7 [secretory granule lumen]

Psmd7 [extracellular region]

Psmd7 [ficolin-1-rich granule lumen]

Psmd7 [cytosol]

Inferred From

PSMD7 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034947.1

ENSEMBL

ENSMUSP00000041968, ENSMUSG00000039067, ENSMUST00000044106

PRO

P26516

MGI

1351511

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