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CCDC22 [nucleoplasm]
Stable Identifier
R-HSA-8955644
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Coiled-coil domain-containing protein 22, CCD22_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
NEDD8:AcM-UBE2M binds CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
CCDC22 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60826 CCDC22
Gene Names
CCDC22, CXorf37, JM1
Chain
chain:1-627
Reference Genes
BioGPS Gene:28952 CCDC22
COSMIC (genes):CCDC22 CCDC22
CTD Gene:28952 CCDC22
dbSNP Gene:28952 CCDC22
ENSEMBL:ENSG00000101997 CCDC22
HGNC:28909 CCDC22
KEGG:hsa:28952 CCDC22
Monarch:28952 CCDC22
NCBI Gene:28952 CCDC22
OMIM:300859 CCDC22
UCSC:O60826 CCDC22
Reference Transcript
RefSeq:NM_014008.4 CCDC22
Other Identifiers
11720706_at
17103572
206016_PM_at
206016_at
214037_PM_s_at
214037_s_at
28952
39587_at
3977084
3977085
3977086
3977089
3977090
3977091
3977092
3977094
3977095
3977096
3977097
3977098
3977099
3977100
3977101
3977102
3977104
3977105
3977106
3977107
3977108
3977109
8167457
A_23_P114144
GE55165
GO:0005515
GO:0005575
GO:0005654
GO:0005737
GO:0005768
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006355
GO:0006878
GO:0006893
GO:0007253
GO:0015031
GO:0016192
GO:0031410
GO:0032456
GO:0043123
GO:0043124
GO:0043226
GO:0097602
GO:2000060
HMNXSV003038523
HMNXSV003039961
Hs.26333.1.A1_3p_a_at
ILMN_1781234
PH_hs_0002323
TC0X000269.hg
Participates
as a component of
COMMDs:CCDC22 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CCDC22 [cytosol]
Inferred To
Ghost homologue of CCDC22 [nucleoplasm]
(Gallus gallus)
Ghost homologue of CCDC22 [nucleoplasm]
(Schizosaccharomyces pombe)
ccdc22 [nucleoplasm]
(Danio rerio)
ccdc22 [nucleoplasm]
(Xenopus tropicalis)
CCDC22 [nucleoplasm]
(Bos taurus)
CCDC22 [nucleoplasm]
(Caenorhabditis elegans)
CCDC22 [nucleoplasm]
(Canis familiaris)
CCDC22 [nucleoplasm]
(Dictyostelium discoideum)
CCDC22 [nucleoplasm]
(Drosophila melanogaster)
CCDC22 [nucleoplasm]
(Sus scrofa)
Ccdc22 [nucleoplasm]
(Mus musculus)
Ccdc22 [nucleoplasm]
(Rattus norvegicus)
Cross References
ENSEMBL
ENSP00000365401
,
ENST00000376227
OpenTargets
ENSG00000101997
HPA
ENSG00000101997-CCDC22
PRO
O60826
Pharos - Targets
O60826
GlyGen
O60826
Orphanet
CCDC22
PDB
8P0V
,
8P0W
,
8P0X
,
8F2U
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H267 VPS33B
3
VPS33B [cytosol]
(R-HSA-9636417)
p-Y133-VPS33B [cytosol]
(R-HSA-9636380)
VPS33B [endosome membrane]
(R-HSA-2197801)
0.643
7
UniProt:Q13614 MTMR2
1
MTMR2 [cytosol]
(R-HSA-1604662)
0.643
5
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.576
3
UniProt:Q96PC5 MIA2
1
MIA2 [endoplasmic reticulum membrane]
(R-HSA-9637821)
0.527
2
UniProt:P51665 PSMD7
5
PSMD7 [cytosol]
(R-HSA-68806)
PSMD7 [nucleoplasm]
(R-HSA-174309)
PSMD7 [secretory granule lumen]
(R-HSA-6801008)
PSMD7 [extracellular region]
(R-HSA-6806488)
PSMD7 [ficolin-1-rich granule lumen]
(R-HSA-6800406)
0.527
2
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