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About
What is Reactome ?
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Team
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Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
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Pathway Diagrams
Icon Info
Data Model
Computational inferred events
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I(1,4,5)P3
Stable Identifier
R-ALL-114520
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
IP3, 1D-myo-inositol 1,4,5-trisphosphate, D-myo-Inositol 1,4,5-trisphosphate, Inositol 1,4,5-trisphosphate, phosphatidylinositol 1,4,5-trisphosphate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Arabidopsis thaliana
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Oryza sativa
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Taeniopygia guttata
Xenopus tropicalis
Expand all
Hemostasis (Arabidopsis thaliana)
Platelet activation, signaling and aggregation (Arabidopsis thaliana)
GPVI-mediated activation cascade (Arabidopsis thaliana)
PLC gamma 2-mediated PIP2 hydrolysis (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Immune System (Arabidopsis thaliana)
Adaptive Immune System (Arabidopsis thaliana)
TCR signaling (Arabidopsis thaliana)
Generation of second messenger molecules (Arabidopsis thaliana)
PLC-gamma1 hydrolyses PIP2 (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Innate Immune System (Arabidopsis thaliana)
C-type lectin receptors (CLRs) (Arabidopsis thaliana)
CLEC7A (Dectin-1) signaling (Arabidopsis thaliana)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Metabolism (Arabidopsis thaliana)
Inositol phosphate metabolism (Arabidopsis thaliana)
Synthesis of IP2, IP, and Ins in the cytosol (Arabidopsis thaliana)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Arabidopsis thaliana)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Arabidopsis thaliana)
Regulation of insulin secretion (Arabidopsis thaliana)
Acetylcholine regulates insulin secretion (Arabidopsis thaliana)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Arabidopsis thaliana)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Arabidopsis thaliana)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Signal Transduction (Arabidopsis thaliana)
Signaling by GPCR (Arabidopsis thaliana)
GPCR downstream signalling (Arabidopsis thaliana)
G alpha (i) signalling events (Arabidopsis thaliana)
Opioid Signalling (Arabidopsis thaliana)
G-protein mediated events (Arabidopsis thaliana)
PLC beta mediated events (Arabidopsis thaliana)
PIP2 hydrolysis (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Arabidopsis thaliana)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Arabidopsis thaliana)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Arabidopsis thaliana)
I(1,4,5)P3 [cytosol]
Hemostasis (Bos taurus)
Platelet activation, signaling and aggregation (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Binding of IP3 to IP3 receptor (Bos taurus)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Bos taurus)
PLC gamma 2-mediated PIP2 hydrolysis (Bos taurus)
I(1,4,5)P3 [cytosol]
Immune System (Bos taurus)
Adaptive Immune System (Bos taurus)
Signaling by the B Cell Receptor (BCR) (Bos taurus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Bos taurus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Bos taurus)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Bos taurus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
TCR signaling (Bos taurus)
Generation of second messenger molecules (Bos taurus)
PLC-gamma1 hydrolyses PIP2 (Bos taurus)
I(1,4,5)P3 [cytosol]
Innate Immune System (Bos taurus)
C-type lectin receptors (CLRs) (Bos taurus)
CLEC7A (Dectin-1) signaling (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Bos taurus)
FCERI mediated Ca+2 mobilization (Bos taurus)
Hydrolysis of PIP2 by PLCG (Bos taurus)
I(1,4,5)P3 [cytosol]
Metabolism (Bos taurus)
Inositol phosphate metabolism (Bos taurus)
Synthesis of IP2, IP, and Ins in the cytosol (Bos taurus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Bos taurus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Bos taurus)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Bos taurus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Bos taurus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Bos taurus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Bos taurus)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Bos taurus)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Bos taurus)
Regulation of insulin secretion (Bos taurus)
Acetylcholine regulates insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Bos taurus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Bos taurus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Bos taurus)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Bos taurus)
ER calcium channels open in response to activated PKA (Bos taurus)
Ca-channel (open) [endoplasmic reticulum membrane] (Bos taurus)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Bos taurus)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Bos taurus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR downstream signalling (Bos taurus)
G alpha (i) signalling events (Bos taurus)
Opioid Signalling (Bos taurus)
G-protein mediated events (Bos taurus)
PLC beta mediated events (Bos taurus)
PIP2 hydrolysis (Bos taurus)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Bos taurus)
Effects of PIP2 hydrolysis (Bos taurus)
Binding of IP3 to IP3 receptor (Bos taurus)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Bos taurus)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Bos taurus)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Bos taurus)
G beta:gamma signalling through PLC beta (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Bos taurus)
Beta-catenin independent WNT signaling (Bos taurus)
Ca2+ pathway (Bos taurus)
PLC beta-mediated PIP2 hydrolysis (Bos taurus)
I(1,4,5)P3 [cytosol]
Hemostasis (Caenorhabditis elegans)
Platelet activation, signaling and aggregation (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Binding of IP3 to IP3 receptor (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Caenorhabditis elegans)
PLC gamma 2-mediated PIP2 hydrolysis (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Immune System (Caenorhabditis elegans)
Adaptive Immune System (Caenorhabditis elegans)
Signaling by the B Cell Receptor (BCR) (Caenorhabditis elegans)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Caenorhabditis elegans)
STIM1 oligomerizes (Caenorhabditis elegans)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
TCR signaling (Caenorhabditis elegans)
Generation of second messenger molecules (Caenorhabditis elegans)
PLC-gamma1 hydrolyses PIP2 (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Innate Immune System (Caenorhabditis elegans)
C-type lectin receptors (CLRs) (Caenorhabditis elegans)
CLEC7A (Dectin-1) signaling (Caenorhabditis elegans)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Metabolism (Caenorhabditis elegans)
Inositol phosphate metabolism (Caenorhabditis elegans)
Synthesis of IP2, IP, and Ins in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Caenorhabditis elegans)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Caenorhabditis elegans)
Regulation of insulin secretion (Caenorhabditis elegans)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Caenorhabditis elegans)
ER calcium channels open in response to activated PKA (Caenorhabditis elegans)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR downstream signalling (Caenorhabditis elegans)
G alpha (i) signalling events (Caenorhabditis elegans)
Opioid Signalling (Caenorhabditis elegans)
G-protein mediated events (Caenorhabditis elegans)
PLC beta mediated events (Caenorhabditis elegans)
PIP2 hydrolysis (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Caenorhabditis elegans)
Effects of PIP2 hydrolysis (Caenorhabditis elegans)
Binding of IP3 to IP3 receptor (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Caenorhabditis elegans)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Caenorhabditis elegans)
I(1,4,5)P3 [cytosol]
Hemostasis (Canis familiaris)
Platelet activation, signaling and aggregation (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Binding of IP3 to IP3 receptor (Canis familiaris)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Canis familiaris)
PLC gamma 2-mediated PIP2 hydrolysis (Canis familiaris)
I(1,4,5)P3 [cytosol]
Immune System (Canis familiaris)
Adaptive Immune System (Canis familiaris)
Signaling by the B Cell Receptor (BCR) (Canis familiaris)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Canis familiaris)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Canis familiaris)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Canis familiaris)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
TCR signaling (Canis familiaris)
Generation of second messenger molecules (Canis familiaris)
PLC-gamma1 hydrolyses PIP2 (Canis familiaris)
I(1,4,5)P3 [cytosol]
Innate Immune System (Canis familiaris)
C-type lectin receptors (CLRs) (Canis familiaris)
CLEC7A (Dectin-1) signaling (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Canis familiaris)
FCERI mediated Ca+2 mobilization (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
I(1,4,5)P3 [cytosol]
Metabolism (Canis familiaris)
Inositol phosphate metabolism (Canis familiaris)
Synthesis of IP2, IP, and Ins in the cytosol (Canis familiaris)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Canis familiaris)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Canis familiaris)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Canis familiaris)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Canis familiaris)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Canis familiaris)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Canis familiaris)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Canis familiaris)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Canis familiaris)
Regulation of insulin secretion (Canis familiaris)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Canis familiaris)
ER calcium channels open in response to activated PKA (Canis familiaris)
Ca-channel (open) [endoplasmic reticulum membrane] (Canis familiaris)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Canis familiaris)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR downstream signalling (Canis familiaris)
G alpha (i) signalling events (Canis familiaris)
Opioid Signalling (Canis familiaris)
G-protein mediated events (Canis familiaris)
PLC beta mediated events (Canis familiaris)
PIP2 hydrolysis (Canis familiaris)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Canis familiaris)
Effects of PIP2 hydrolysis (Canis familiaris)
Binding of IP3 to IP3 receptor (Canis familiaris)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Canis familiaris)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Canis familiaris)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Canis familiaris)
G beta:gamma signalling through PLC beta (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Canis familiaris)
Beta-catenin independent WNT signaling (Canis familiaris)
Ca2+ pathway (Canis familiaris)
PLC beta-mediated PIP2 hydrolysis (Canis familiaris)
I(1,4,5)P3 [cytosol]
Hemostasis (Danio rerio)
Platelet activation, signaling and aggregation (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Binding of IP3 to IP3 receptor (Danio rerio)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Danio rerio)
PLC gamma 2-mediated PIP2 hydrolysis (Danio rerio)
I(1,4,5)P3 [cytosol]
Immune System (Danio rerio)
Adaptive Immune System (Danio rerio)
Signaling by the B Cell Receptor (BCR) (Danio rerio)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Danio rerio)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Danio rerio)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Danio rerio)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
TCR signaling (Danio rerio)
Generation of second messenger molecules (Danio rerio)
PLC-gamma1 hydrolyses PIP2 (Danio rerio)
I(1,4,5)P3 [cytosol]
Innate Immune System (Danio rerio)
C-type lectin receptors (CLRs) (Danio rerio)
CLEC7A (Dectin-1) signaling (Danio rerio)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Danio rerio)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Danio rerio)
FCERI mediated Ca+2 mobilization (Danio rerio)
Hydrolysis of PIP2 by PLCG (Danio rerio)
I(1,4,5)P3 [cytosol]
Metabolism (Danio rerio)
Inositol phosphate metabolism (Danio rerio)
Synthesis of IP2, IP, and Ins in the cytosol (Danio rerio)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Danio rerio)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Danio rerio)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Danio rerio)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Danio rerio)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Danio rerio)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Danio rerio)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Danio rerio)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Danio rerio)
Regulation of insulin secretion (Danio rerio)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Danio rerio)
ER calcium channels open in response to activated PKA (Danio rerio)
Ca-channel (open) [endoplasmic reticulum membrane] (Danio rerio)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Danio rerio)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Danio rerio)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR downstream signalling (Danio rerio)
G alpha (i) signalling events (Danio rerio)
Opioid Signalling (Danio rerio)
G-protein mediated events (Danio rerio)
PLC beta mediated events (Danio rerio)
PIP2 hydrolysis (Danio rerio)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Danio rerio)
Effects of PIP2 hydrolysis (Danio rerio)
Binding of IP3 to IP3 receptor (Danio rerio)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Danio rerio)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Danio rerio)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Danio rerio)
G beta:gamma signalling through PLC beta (Danio rerio)
PLC beta-mediated PIP2 hydrolysis (Danio rerio)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Danio rerio)
Beta-catenin independent WNT signaling (Danio rerio)
Ca2+ pathway (Danio rerio)
PLC beta-mediated PIP2 hydrolysis (Danio rerio)
I(1,4,5)P3 [cytosol]
Hemostasis (Dictyostelium discoideum)
Platelet activation, signaling and aggregation (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Binding of IP3 to IP3 receptor (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
Metabolism (Dictyostelium discoideum)
Inositol phosphate metabolism (Dictyostelium discoideum)
Synthesis of IP2, IP, and Ins in the cytosol (Dictyostelium discoideum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Dictyostelium discoideum)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Dictyostelium discoideum)
Regulation of insulin secretion (Dictyostelium discoideum)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Dictyostelium discoideum)
ER calcium channels open in response to activated PKA (Dictyostelium discoideum)
Ca-channel (open) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
Signal Transduction (Dictyostelium discoideum)
Signaling by GPCR (Dictyostelium discoideum)
GPCR downstream signalling (Dictyostelium discoideum)
G alpha (q) signalling events (Dictyostelium discoideum)
Effects of PIP2 hydrolysis (Dictyostelium discoideum)
Binding of IP3 to IP3 receptor (Dictyostelium discoideum)
I(1,4,5)P3 [cytosol]
Hemostasis (Drosophila melanogaster)
Platelet activation, signaling and aggregation (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Binding of IP3 to IP3 receptor (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Drosophila melanogaster)
PLC gamma 2-mediated PIP2 hydrolysis (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Immune System (Drosophila melanogaster)
Adaptive Immune System (Drosophila melanogaster)
Signaling by the B Cell Receptor (BCR) (Drosophila melanogaster)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Drosophila melanogaster)
STIM1 oligomerizes (Drosophila melanogaster)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
TCR signaling (Drosophila melanogaster)
Generation of second messenger molecules (Drosophila melanogaster)
PLC-gamma1 hydrolyses PIP2 (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Innate Immune System (Drosophila melanogaster)
C-type lectin receptors (CLRs) (Drosophila melanogaster)
CLEC7A (Dectin-1) signaling (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Metabolism (Drosophila melanogaster)
Inositol phosphate metabolism (Drosophila melanogaster)
Synthesis of IP2, IP, and Ins in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Drosophila melanogaster)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Drosophila melanogaster)
Regulation of insulin secretion (Drosophila melanogaster)
Acetylcholine regulates insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Drosophila melanogaster)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Drosophila melanogaster)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Drosophila melanogaster)
ER calcium channels open in response to activated PKA (Drosophila melanogaster)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Ion homeostasis (Drosophila melanogaster)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Drosophila melanogaster)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Drosophila melanogaster)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR downstream signalling (Drosophila melanogaster)
G alpha (i) signalling events (Drosophila melanogaster)
Opioid Signalling (Drosophila melanogaster)
G-protein mediated events (Drosophila melanogaster)
PLC beta mediated events (Drosophila melanogaster)
PIP2 hydrolysis (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Drosophila melanogaster)
Effects of PIP2 hydrolysis (Drosophila melanogaster)
Binding of IP3 to IP3 receptor (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Drosophila melanogaster)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Drosophila melanogaster)
I(1,4,5)P3 [cytosol]
Hemostasis (Gallus gallus)
Platelet activation, signaling and aggregation (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Binding of IP3 to IP3 receptor (Gallus gallus)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Gallus gallus)
PLC gamma 2-mediated PIP2 hydrolysis (Gallus gallus)
I(1,4,5)P3 [cytosol]
Immune System (Gallus gallus)
Adaptive Immune System (Gallus gallus)
Signaling by the B Cell Receptor (BCR) (Gallus gallus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Gallus gallus)
STIM1 oligomerizes (Gallus gallus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
TCR signaling (Gallus gallus)
Generation of second messenger molecules (Gallus gallus)
PLC-gamma1 hydrolyses PIP2 (Gallus gallus)
I(1,4,5)P3 [cytosol]
Innate Immune System (Gallus gallus)
C-type lectin receptors (CLRs) (Gallus gallus)
CLEC7A (Dectin-1) signaling (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Gallus gallus)
FCERI mediated Ca+2 mobilization (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
I(1,4,5)P3 [cytosol]
Metabolism (Gallus gallus)
Inositol phosphate metabolism (Gallus gallus)
Synthesis of IP2, IP, and Ins in the cytosol (Gallus gallus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Gallus gallus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Gallus gallus)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Gallus gallus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Gallus gallus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Gallus gallus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Gallus gallus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Gallus gallus)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Gallus gallus)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Gallus gallus)
Regulation of insulin secretion (Gallus gallus)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Gallus gallus)
ER calcium channels open in response to activated PKA (Gallus gallus)
Ca-channel (open) [endoplasmic reticulum membrane] (Gallus gallus)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Gallus gallus)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Gallus gallus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR downstream signalling (Gallus gallus)
G alpha (i) signalling events (Gallus gallus)
Opioid Signalling (Gallus gallus)
G-protein mediated events (Gallus gallus)
PLC beta mediated events (Gallus gallus)
PIP2 hydrolysis (Gallus gallus)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Gallus gallus)
Effects of PIP2 hydrolysis (Gallus gallus)
Binding of IP3 to IP3 receptor (Gallus gallus)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Gallus gallus)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Gallus gallus)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Gallus gallus)
G beta:gamma signalling through PLC beta (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Gallus gallus)
Beta-catenin independent WNT signaling (Gallus gallus)
Ca2+ pathway (Gallus gallus)
PLC beta-mediated PIP2 hydrolysis (Gallus gallus)
I(1,4,5)P3 [cytosol]
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Homo sapiens)
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
I(1,4,5)P3 [cytosol]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
PLC-gamma1 hydrolyses PIP2 (Homo sapiens)
I(1,4,5)P3 [cytosol]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Homo sapiens)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Metabolism (Homo sapiens)
Inositol phosphate metabolism (Homo sapiens)
IP3 and IP4 transport between cytosol and nucleus (Homo sapiens)
I(1,4,5)P3 transports from the cytosol to the nucleus (Homo sapiens)
I(1,4,5)P3 [cytosol]
IPs transport between ER lumen and cytosol (Homo sapiens)
I(1,4,5)P3 transports from the ER lumen to the cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
Synthesis of IP2, IP, and Ins in the cytosol (Homo sapiens)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Homo sapiens)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Homo sapiens)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Homo sapiens)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Homo sapiens)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Homo sapiens)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Acetylcholine regulates insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Homo sapiens)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Homo sapiens)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Homo sapiens)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Homo sapiens)
ER calcium channels open in response to activated PKA (Homo sapiens)
Ca-channel (open) [endoplasmic reticulum membrane] (Homo sapiens)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Homo sapiens)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
PIP2 hydrolysis (Homo sapiens)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Homo sapiens)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Homo sapiens)
G beta:gamma signalling through PLC beta (Homo sapiens)
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
I(1,4,5)P3 [cytosol]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
I(1,4,5)P3 [cytosol]
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel (Homo sapiens)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Homo sapiens)
I(1,4,5)P3 [cytosol]
PLC beta-mediated PIP2 hydrolysis (Homo sapiens)
I(1,4,5)P3 [cytosol]
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Binding of IP3 to IP3 receptor (Mus musculus)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Mus musculus)
PLC gamma 2-mediated PIP2 hydrolysis (Mus musculus)
I(1,4,5)P3 [cytosol]
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Mus musculus)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Mus musculus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
TCR signaling (Mus musculus)
Generation of second messenger molecules (Mus musculus)
PLC-gamma1 hydrolyses PIP2 (Mus musculus)
I(1,4,5)P3 [cytosol]
Innate Immune System (Mus musculus)
C-type lectin receptors (CLRs) (Mus musculus)
CLEC7A (Dectin-1) signaling (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
I(1,4,5)P3 [cytosol]
Metabolism (Mus musculus)
Inositol phosphate metabolism (Mus musculus)
Synthesis of IP2, IP, and Ins in the cytosol (Mus musculus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Mus musculus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Mus musculus)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Mus musculus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Mus musculus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Mus musculus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Mus musculus)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Mus musculus)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Mus musculus)
Regulation of insulin secretion (Mus musculus)
Acetylcholine regulates insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Mus musculus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Mus musculus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Mus musculus)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Mus musculus)
ER calcium channels open in response to activated PKA (Mus musculus)
Ca-channel (open) [endoplasmic reticulum membrane] (Mus musculus)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Mus musculus)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Mus musculus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (i) signalling events (Mus musculus)
Opioid Signalling (Mus musculus)
G-protein mediated events (Mus musculus)
PLC beta mediated events (Mus musculus)
PIP2 hydrolysis (Mus musculus)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Mus musculus)
Effects of PIP2 hydrolysis (Mus musculus)
Binding of IP3 to IP3 receptor (Mus musculus)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Mus musculus)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Mus musculus)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Mus musculus)
G beta:gamma signalling through PLC beta (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Mus musculus)
Beta-catenin independent WNT signaling (Mus musculus)
Ca2+ pathway (Mus musculus)
PLC beta-mediated PIP2 hydrolysis (Mus musculus)
I(1,4,5)P3 [cytosol]
Hemostasis (Oryza sativa)
Platelet activation, signaling and aggregation (Oryza sativa)
GPVI-mediated activation cascade (Oryza sativa)
PLC gamma 2-mediated PIP2 hydrolysis (Oryza sativa)
I(1,4,5)P3 [cytosol]
Immune System (Oryza sativa)
Adaptive Immune System (Oryza sativa)
TCR signaling (Oryza sativa)
Generation of second messenger molecules (Oryza sativa)
PLC-gamma1 hydrolyses PIP2 (Oryza sativa)
I(1,4,5)P3 [cytosol]
Innate Immune System (Oryza sativa)
C-type lectin receptors (CLRs) (Oryza sativa)
CLEC7A (Dectin-1) signaling (Oryza sativa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Oryza sativa)
I(1,4,5)P3 [cytosol]
Metabolism (Oryza sativa)
Inositol phosphate metabolism (Oryza sativa)
Synthesis of IP2, IP, and Ins in the cytosol (Oryza sativa)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Oryza sativa)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Oryza sativa)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Oryza sativa)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Oryza sativa)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Oryza sativa)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Oryza sativa)
Regulation of insulin secretion (Oryza sativa)
Acetylcholine regulates insulin secretion (Oryza sativa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Oryza sativa)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Oryza sativa)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Oryza sativa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Oryza sativa)
I(1,4,5)P3 [cytosol]
Signal Transduction (Oryza sativa)
Signaling by GPCR (Oryza sativa)
GPCR downstream signalling (Oryza sativa)
G alpha (i) signalling events (Oryza sativa)
Opioid Signalling (Oryza sativa)
G-protein mediated events (Oryza sativa)
PLC beta mediated events (Oryza sativa)
PIP2 hydrolysis (Oryza sativa)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Oryza sativa)
PLC-beta hydrolyses PIP2 to DAG and IP3 (Oryza sativa)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Oryza sativa)
I(1,4,5)P3 [cytosol]
Metabolism (Plasmodium falciparum)
Inositol phosphate metabolism (Plasmodium falciparum)
Synthesis of IP2, IP, and Ins in the cytosol (Plasmodium falciparum)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Plasmodium falciparum)
I(1,4,5)P3 [cytosol]
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Binding of IP3 to IP3 receptor (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Rattus norvegicus)
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Rattus norvegicus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
TCR signaling (Rattus norvegicus)
Generation of second messenger molecules (Rattus norvegicus)
PLC-gamma1 hydrolyses PIP2 (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Metabolism (Rattus norvegicus)
Inositol phosphate metabolism (Rattus norvegicus)
Synthesis of IP2, IP, and Ins in the cytosol (Rattus norvegicus)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Rattus norvegicus)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Rattus norvegicus)
Regulation of insulin secretion (Rattus norvegicus)
Acetylcholine regulates insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Rattus norvegicus)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Rattus norvegicus)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Rattus norvegicus)
ER calcium channels open in response to activated PKA (Rattus norvegicus)
Ca-channel (open) [endoplasmic reticulum membrane] (Rattus norvegicus)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Rattus norvegicus)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Rattus norvegicus)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Opioid Signalling (Rattus norvegicus)
G-protein mediated events (Rattus norvegicus)
PLC beta mediated events (Rattus norvegicus)
PIP2 hydrolysis (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Rattus norvegicus)
Effects of PIP2 hydrolysis (Rattus norvegicus)
Binding of IP3 to IP3 receptor (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Rattus norvegicus)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Rattus norvegicus)
I(1,4,5)P3 [cytosol]
Hemostasis (Saccharomyces cerevisiae)
Platelet activation, signaling and aggregation (Saccharomyces cerevisiae)
GPVI-mediated activation cascade (Saccharomyces cerevisiae)
PLC gamma 2-mediated PIP2 hydrolysis (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
Immune System (Saccharomyces cerevisiae)
Adaptive Immune System (Saccharomyces cerevisiae)
TCR signaling (Saccharomyces cerevisiae)
Generation of second messenger molecules (Saccharomyces cerevisiae)
PLC-gamma1 hydrolyses PIP2 (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
Innate Immune System (Saccharomyces cerevisiae)
C-type lectin receptors (CLRs) (Saccharomyces cerevisiae)
CLEC7A (Dectin-1) signaling (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
Metabolism (Saccharomyces cerevisiae)
Inositol phosphate metabolism (Saccharomyces cerevisiae)
Synthesis of IP2, IP, and Ins in the cytosol (Saccharomyces cerevisiae)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Saccharomyces cerevisiae)
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Saccharomyces cerevisiae)
I(1,4,5)P3 [cytosol]
Metabolism (Schizosaccharomyces pombe)
Inositol phosphate metabolism (Schizosaccharomyces pombe)
Synthesis of IP2, IP, and Ins in the cytosol (Schizosaccharomyces pombe)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Schizosaccharomyces pombe)
I(1,4,5)P3 [cytosol]
Hemostasis (Sus scrofa)
Platelet activation, signaling and aggregation (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Binding of IP3 to IP3 receptor (Sus scrofa)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Sus scrofa)
PLC gamma 2-mediated PIP2 hydrolysis (Sus scrofa)
I(1,4,5)P3 [cytosol]
Immune System (Sus scrofa)
Adaptive Immune System (Sus scrofa)
Signaling by the B Cell Receptor (BCR) (Sus scrofa)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Sus scrofa)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Sus scrofa)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Sus scrofa)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
TCR signaling (Sus scrofa)
Generation of second messenger molecules (Sus scrofa)
PLC-gamma1 hydrolyses PIP2 (Sus scrofa)
I(1,4,5)P3 [cytosol]
Innate Immune System (Sus scrofa)
C-type lectin receptors (CLRs) (Sus scrofa)
CLEC7A (Dectin-1) signaling (Sus scrofa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Sus scrofa)
FCERI mediated Ca+2 mobilization (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
I(1,4,5)P3 [cytosol]
Metabolism (Sus scrofa)
Inositol phosphate metabolism (Sus scrofa)
Synthesis of IP2, IP, and Ins in the cytosol (Sus scrofa)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Sus scrofa)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Sus scrofa)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Sus scrofa)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Sus scrofa)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Sus scrofa)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Sus scrofa)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Sus scrofa)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Sus scrofa)
Regulation of insulin secretion (Sus scrofa)
Acetylcholine regulates insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
I(1,4,5)P3 [cytosol]
Free fatty acids regulate insulin secretion (Sus scrofa)
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion (Sus scrofa)
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate (Sus scrofa)
I(1,4,5)P3 [cytosol]
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Sus scrofa)
ER calcium channels open in response to activated PKA (Sus scrofa)
Ca-channel (open) [endoplasmic reticulum membrane] (Sus scrofa)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Ion homeostasis (Sus scrofa)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Sus scrofa)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
Signal Transduction (Sus scrofa)
Signaling by GPCR (Sus scrofa)
GPCR downstream signalling (Sus scrofa)
G alpha (i) signalling events (Sus scrofa)
Opioid Signalling (Sus scrofa)
G-protein mediated events (Sus scrofa)
PLC beta mediated events (Sus scrofa)
PIP2 hydrolysis (Sus scrofa)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Sus scrofa)
Effects of PIP2 hydrolysis (Sus scrofa)
Binding of IP3 to IP3 receptor (Sus scrofa)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Sus scrofa)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Sus scrofa)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Sus scrofa)
G beta:gamma signalling through PLC beta (Sus scrofa)
PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Sus scrofa)
Beta-catenin independent WNT signaling (Sus scrofa)
Ca2+ pathway (Sus scrofa)
PLC beta-mediated PIP2 hydrolysis (Sus scrofa)
I(1,4,5)P3 [cytosol]
Hemostasis (Taeniopygia guttata)
Platelet activation, signaling and aggregation (Taeniopygia guttata)
Effects of PIP2 hydrolysis (Taeniopygia guttata)
Binding of IP3 to IP3 receptor (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Taeniopygia guttata)
PLC gamma 2-mediated PIP2 hydrolysis (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Immune System (Taeniopygia guttata)
Adaptive Immune System (Taeniopygia guttata)
Signaling by the B Cell Receptor (BCR) (Taeniopygia guttata)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Taeniopygia guttata)
STIM1 oligomerizes (Taeniopygia guttata)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
TCR signaling (Taeniopygia guttata)
Generation of second messenger molecules (Taeniopygia guttata)
PLC-gamma1 hydrolyses PIP2 (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Innate Immune System (Taeniopygia guttata)
C-type lectin receptors (CLRs) (Taeniopygia guttata)
CLEC7A (Dectin-1) signaling (Taeniopygia guttata)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Taeniopygia guttata)
FCERI mediated Ca+2 mobilization (Taeniopygia guttata)
Hydrolysis of PIP2 by PLCG (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Metabolism (Taeniopygia guttata)
Inositol phosphate metabolism (Taeniopygia guttata)
Synthesis of IP2, IP, and Ins in the cytosol (Taeniopygia guttata)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Taeniopygia guttata)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Taeniopygia guttata)
Regulation of insulin secretion (Taeniopygia guttata)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Taeniopygia guttata)
ER calcium channels open in response to activated PKA (Taeniopygia guttata)
Ca-channel (open) [endoplasmic reticulum membrane] (Taeniopygia guttata)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Muscle contraction (Taeniopygia guttata)
Cardiac conduction (Taeniopygia guttata)
Ion homeostasis (Taeniopygia guttata)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Taeniopygia guttata)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Taeniopygia guttata)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Signal Transduction (Taeniopygia guttata)
Signaling by GPCR (Taeniopygia guttata)
GPCR downstream signalling (Taeniopygia guttata)
G alpha (i) signalling events (Taeniopygia guttata)
Opioid Signalling (Taeniopygia guttata)
G-protein mediated events (Taeniopygia guttata)
PLC beta mediated events (Taeniopygia guttata)
PIP2 hydrolysis (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Taeniopygia guttata)
Effects of PIP2 hydrolysis (Taeniopygia guttata)
Binding of IP3 to IP3 receptor (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Taeniopygia guttata)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Taeniopygia guttata)
G beta:gamma signalling through PLC beta (Taeniopygia guttata)
PLC beta-mediated PIP2 hydrolysis (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Taeniopygia guttata)
Beta-catenin independent WNT signaling (Taeniopygia guttata)
Ca2+ pathway (Taeniopygia guttata)
PLC beta-mediated PIP2 hydrolysis (Taeniopygia guttata)
I(1,4,5)P3 [cytosol]
Hemostasis (Xenopus tropicalis)
Platelet activation, signaling and aggregation (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Binding of IP3 to IP3 receptor (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
GPVI-mediated activation cascade (Xenopus tropicalis)
PLC gamma 2-mediated PIP2 hydrolysis (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Immune System (Xenopus tropicalis)
Adaptive Immune System (Xenopus tropicalis)
Signaling by the B Cell Receptor (BCR) (Xenopus tropicalis)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Xenopus tropicalis)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
STIM1 oligomerizes (Xenopus tropicalis)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
TCR signaling (Xenopus tropicalis)
Generation of second messenger molecules (Xenopus tropicalis)
PLC-gamma1 hydrolyses PIP2 (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Innate Immune System (Xenopus tropicalis)
C-type lectin receptors (CLRs) (Xenopus tropicalis)
CLEC7A (Dectin-1) signaling (Xenopus tropicalis)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Fc epsilon receptor (FCERI) signaling (Xenopus tropicalis)
FCERI mediated Ca+2 mobilization (Xenopus tropicalis)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Metabolism (Xenopus tropicalis)
Inositol phosphate metabolism (Xenopus tropicalis)
Synthesis of IP2, IP, and Ins in the cytosol (Xenopus tropicalis)
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Synthesis of IP3 and IP4 in the cytosol (Xenopus tropicalis)
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Integration of energy metabolism (Xenopus tropicalis)
Regulation of insulin secretion (Xenopus tropicalis)
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (Xenopus tropicalis)
ER calcium channels open in response to activated PKA (Xenopus tropicalis)
Ca-channel (open) [endoplasmic reticulum membrane] (Xenopus tropicalis)
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Ion homeostasis (Xenopus tropicalis)
AHCYL1:NAD+ binds ITPR1:I(1,3,5)P3 tetramer, inhibiting it (Xenopus tropicalis)
AHCYL1:NAD+:ITPR1:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Xenopus tropicalis)
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by GPCR (Xenopus tropicalis)
GPCR downstream signalling (Xenopus tropicalis)
G alpha (i) signalling events (Xenopus tropicalis)
Opioid Signalling (Xenopus tropicalis)
G-protein mediated events (Xenopus tropicalis)
PLC beta mediated events (Xenopus tropicalis)
PIP2 hydrolysis (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
G alpha (q) signalling events (Xenopus tropicalis)
Effects of PIP2 hydrolysis (Xenopus tropicalis)
Binding of IP3 to IP3 receptor (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
PLC-beta hydrolyses PIP2 to DAG and IP3 (Xenopus tropicalis)
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane] (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
G-protein beta:gamma signalling (Xenopus tropicalis)
G beta:gamma signalling through PLC beta (Xenopus tropicalis)
PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
Signaling by WNT (Xenopus tropicalis)
Beta-catenin independent WNT signaling (Xenopus tropicalis)
Ca2+ pathway (Xenopus tropicalis)
PLC beta-mediated PIP2 hydrolysis (Xenopus tropicalis)
I(1,4,5)P3 [cytosol]
External Reference Information
External Reference
1D-myo-inositol 1,4,5-trisphosphate [ChEBI:16595]
Participant Of
input
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
Binding of IP3 to IP3 receptor
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,4,5)P3 transports from the cytosol to the nucleus
IP3 binds to the IP3 receptor, opening the Ca2+ channel
IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
output
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Active PLCG1 hydrolyses PIP2
Active Plcg1 hydrolyses PIP2
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
Hydrolysis of PIP2 by PLCG
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,4,5)P3 transports from the ER lumen to the cytosol
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
p-Y753,Y759-PLCG2 hydrolyses PIP2
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PIP2 hydrolysis
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC beta-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC gamma 2-mediated PIP2 hydrolysis
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
PLC-gamma1 hydrolyses PIP2
hasComponent
IP3 receptor:IP3 [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 1 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 2 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
IP3-gated Ca-channel type 3 (open) [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
ITPR:I(1,4,5)P3 tetramer [endoplasmic reticulum membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
PLC-beta:G-alpha(q/11):DAG:IP3 [plasma membrane]
This entity regulates
Positive Regulation
Positive regulation by 'I(1,4,5)P3 [cytosol]'
Other forms of this molecule
I(1,4,5)P3 [nucleoplasm]
I(1,4,5)P3 [platelet dense tubular network membrane]
I(1,4,5)P3 [endoplasmic reticulum lumen]
Cross References
COMPOUND
C01245
PubChem Substance
8143490
HMDB Metabolite
HMDB0001498
ZINC
000004095598
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