BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Stable Identifier
Reaction [transition]
Homo sapiens
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Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).
Literature References
PubMed ID Title Journal Year
1376928 Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes

McHugh, JC, Coggeshall, KM, Altman, A

Proc Natl Acad Sci U S A 1992
1705565 Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation

Roifman, CM, Gazit, A, Padeh, S, Levitzki, A, Mills, GB

J Clin Invest 1991
1599430 Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells

Scheibel, MS, Lane, PJ, Clark, EA, McConnell, FM, Shears, SB

Biochem J 1992
1374290 Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: potential role in PKC activation

Bomsztyk, K, Ostrowski, J, Pollok, BA, Valentine, MA, Harris, WE, Clark, EA, Draves, KE, Bursten, SL

Cell Immunol 1992
3500860 Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation

Roifman, CM, Grinstein, S, Cheung, RK, Gelfand, EW, Mills, GB, Stewart, D

Eur J Immunol 1987
12181444 Activation of phospholipase Cgamma2 by tyrosine phosphorylation

Ashby, B, Dangelmaier, C, Kunapuli, SP, Daniel, JL, Ozdener, F

Mol Pharmacol 2002
2011584 Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes

Rhee, SG, Carter, RH, Fearon, DT, Park, DJ

Proc Natl Acad Sci U S A 1991
Catalyst Activity

phospholipase C activity of BLNK (SLP-65) Signalosome [plasma membrane]

Orthologous Events
Cross References
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