Reactome | BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Stable Identifier

R-HSA-1112666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

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Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1376928	Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes McHugh, JC, Coggeshall, KM, Altman, A	Proc Natl Acad Sci U S A	1992
1705565	Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation Roifman, CM, Gazit, A, Padeh, S, Levitzki, A, Mills, GB	J Clin Invest	1991
1599430	Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells Scheibel, MS, Lane, PJ, Clark, EA, McConnell, FM, Shears, SB	Biochem J	1992
1374290	Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: potential role in PKC activation Bomsztyk, K, Ostrowski, J, Pollok, BA, Valentine, MA, Harris, WE, Clark, EA, Draves, KE, Bursten, SL	Cell Immunol	1992
3500860	Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation Roifman, CM, Grinstein, S, Cheung, RK, Gelfand, EW, Mills, GB, Stewart, D	Eur J Immunol	1987
12181444	Activation of phospholipase Cgamma2 by tyrosine phosphorylation Ashby, B, Dangelmaier, C, Kunapuli, SP, Daniel, JL, Ozdener, F	Mol Pharmacol	2002
2011584	Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes Rhee, SG, Carter, RH, Fearon, DT, Park, DJ	Proc Natl Acad Sci U S A	1991