BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate

Stable Identifier
R-HSA-1112666
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).

Literature References
PubMed ID Title Journal Year
1705565 Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation

Padeh, S, Levitzki, A, Gazit, A, Mills, GB, Roifman, CM

J Clin Invest 1991
1376928 Predominant expression and activation-induced tyrosine phosphorylation of phospholipase C-gamma 2 in B lymphocytes

Coggeshall, KM, McHugh, JC, Altman, A

Proc Natl Acad Sci U S A 1992
1599430 Relationships between the degree of cross-linking of surface immunoglobulin and the associated inositol 1,4,5-trisphosphate and Ca2+ signals in human B cells

McConnell, FM, Shears, SB, Lane, PJ, Scheibel, MS, Clark, EA

Biochem J 1992
1374290 Generation of phosphatidic acid and diacylglycerols following ligation of surface immunoglobulin in human B lymphocytes: potential role in PKC activation

Valentine, MA, Bursten, SL, Harris, WE, Draves, KE, Pollok, BA, Ostrowski, J, Bomsztyk, K, Clark, EA

Cell Immunol 1992
3500860 Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation

Roifman, CM, Mills, GB, Stewart, D, Cheung, RK, Grinstein, S, Gelfand, EW

Eur J Immunol 1987
12181444 Activation of phospholipase Cgamma2 by tyrosine phosphorylation

Ozdener, F, Dangelmaier, C, Ashby, B, Kunapuli, SP, Daniel, JL

Mol Pharmacol 2002
2011584 Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes

Carter, RH, Park, DJ, Rhee, SG, Fearon, DT

Proc Natl Acad Sci U S A 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase C activity of BLNK (SLP-65) Signalosome [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created