Reactome | PLC-gamma1 hydrolyses PIP2

PLC-gamma1 hydrolyses PIP2

Stable Identifier

R-HSA-202407

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
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        FCGR3A-mediated IL10 synthesis (Homo sapiens)
        
        PLC-gamma1 hydrolyses PIP2 (Homo sapiens)

General

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On recruitment to plasma membrane PLC-gamma1 then hydrolyses PIP2 producing two second messengers, diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). IP3 induces a transient increase in intracellular free Ca++, while DAG is a direct activator of protein kinase C (PKC theta). These process have been implicated in many cellular physiological functions like cell proliferation, cell growth and differentiation.

Literature References