IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel

Stable Identifier
R-HSA-169680
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane
ReviewStatus
5/5
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IP3 binds to the IP3 receptor, opening the endoplasmic reticulum Ca2+ channel
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The IP3 receptor (IP3R) is an IP3-gated calcium channel. It is a large, homotetrameric protein, similar to other calcium channel proteins such as ryanodine. The four subunits form a 'four-leafed clover' structure arranged around the central calcium channel. Binding of ligands such as IP3 results in conformational changes in the receptor's structure that leads to channel opening.
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Output
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as an event of
Catalyst Activity

ligand-gated calcium channel activity of ITPR tetramers [endoplasmic reticulum membrane]

Physical Entity
ITPR tetramers [endoplasmic reticulum membrane] (Homo sapiens)
Activity
ligand-gated calcium channel activity (GO:0099604)
Inferred From
IP3 binds to the IP3 receptor, opening the Ca2+ channel (Rattus norvegicus)
Authored
Le Novere, N  (2004-03-31)
Jassal, B  (2004-03-31)
Reviewed
Gillespie, ME  (2009-06-02)
Hill, DP  (2025-06-02)
Created
Jassal, B  (2005-11-30)
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