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Binding of IP3 to IP3 receptor
Stable Identifier
R-HSA-139941
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
platelet dense tubular network membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
General
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The IP3 receptor (IP3R) is an intracellular calcium release channel that mobilizes Ca2+ from internal stores in the ER to the cytoplasm. Though its activity is stimulated by IP3, the principal activator of the IP3R is Ca2+. This process of calcium-induced calcium release is central to the mechanism of Ca2+ signalling. The effect of cytosolic Ca2+ on IP3R is complex: it can be both stimulatory and inhibitory and can the effect varies between IP3R isoforms. In general, the IP3Rs have a bell-shaped Ca2+ dependence when treated with low concentrations of IP3; low concentrations of Ca2+ (100–300 nM) are stimulatory but above 300 nM, Ca2+ becomes inhibitory and switches the channel off. The stimulatory effect of IP3 is to relieve Ca2+ inhibition of the channel, enabling Ca2+ activation sites to gate it.
Functionally the IP3 receptor is believed to be tetrameric, with results indicating that the tetramer is composed of 2 pairs of protein isoforms.
Literature References
PubMed ID
Title
Journal
Year
11413485
The versatility and universality of calcium signalling
Berridge, MJ
,
Bootman, MD
,
Lipp, P
Nat Rev Mol Cell Biol
2000
Participants
Input
I(1,4,5)P3 [cytosol]
IP3R tetramer [platelet dense tubular network membrane]
(Homo sapiens)
Output
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane]
(Homo sapiens)
Participates
as an event of
Effects of PIP2 hydrolysis (Homo sapiens)
Orthologous Events
Binding of IP3 to IP3 receptor (Bos taurus)
Binding of IP3 to IP3 receptor (Caenorhabditis elegans)
Binding of IP3 to IP3 receptor (Canis familiaris)
Binding of IP3 to IP3 receptor (Dictyostelium discoideum)
Binding of IP3 to IP3 receptor (Drosophila melanogaster)
Binding of IP3 to IP3 receptor (Gallus gallus)
Binding of IP3 to IP3 receptor (Mus musculus)
Binding of IP3 to IP3 receptor (Rattus norvegicus)
Binding of IP3 to IP3 receptor (Sus scrofa)
Binding of IP3 to IP3 receptor (Xenopus tropicalis)
Created
Farndale, R (2004-09-25)
Pace, NP (2004-09-25)
de Bono, B (2004-09-25)
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