Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Stable Identifier
R-MMU-9032476
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Phospholipase C gamma (Plcg1 or Plcg2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (Epor) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Beckman et al. 1996, and inferred from human homologs). Erythropoietin also activates the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (Beckman et al. 1996),

Literature References
PubMed ID Title Journal Year
8615781 Molecular species of phospholipids in a murine stem-cell line responsive to erythropoietin

Beckman, BS, Mallia, C, Clejan, S

Biochem. J. 1996
Participants
Catalyst Activity

phosphatidylinositol phospholipase C activity of Epo:p-8Y-Epor:p-12Y-Jak2:Lyn:Irs2:p-Y-Plcg1,2 [plasma membrane]

Orthologous Events
Authored
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