I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol

Stable Identifier
R-HSA-1855153
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Inositol-trisphosphate 3-kinase A (ITPKA), B (ITPKB), and C (ITPKC) phosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Dewaste et al. 2003).

Literature References
PubMed ID Title Journal Year
12747803 The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells

Dewaste, V, Moreau, C, De Smedt, F, Bex, F, De Smedt, H, Wuytack, F, Missiaen, L, Erneux, C

Biochem J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
inositol-1,4,5-trisphosphate 3-kinase activity of ITPKA/B/C [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created