I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol

Stable Identifier
R-HSA-1855153
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
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Inositol-trisphosphate 3-kinase A (ITPKA), B (ITPKB), and C (ITPKC) phosphorylate inositol 1,4,5-trisphosphate (I(1,4,5)P3) to inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) (Dewaste et al. 2003).

Literature References
PubMed ID Title Journal Year
12747803 The three isoenzymes of human inositol-1,4,5-trisphosphate 3-kinase show specific intracellular localization but comparable Ca2+ responses on transfection in COS-7 cells

Missiaen, L, Wuytack, F, Erneux, C, Dewaste, V, De Smedt, H, De Smedt, F, Moreau, C, Bex, F

Biochem J 2003
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as an event of
Catalyst Activity

inositol-1,4,5-trisphosphate 3-kinase activity of ITPKA/B/C [cytosol]

Physical Entity
ITPKA/B/C [cytosol] (Homo sapiens)
Activity
inositol-1,4,5-trisphosphate 3-kinase activity (GO:0008440)
Orthologous Events
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Bos taurus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Caenorhabditis elegans)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Canis familiaris)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Danio rerio)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Dictyostelium discoideum)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Drosophila melanogaster)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Gallus gallus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Mus musculus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Rattus norvegicus)
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol (Sus scrofa)
Cross References
Rhea
Authored
Williams, MG  (2011-10-28)
Created
Williams, MG  (2011-10-28)
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