EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Stable Identifier
R-HSA-9032478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phospholipase C gamma (PLCG1 or PLCG2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (EPOR) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Ren et al. 1994, and inferred from mouse). Erythropoietin may also activate the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (inferred from mouse homologs),

Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Komatsu, N, Shimizu, R, Okada, K, Miura, Y

J. Biol. Chem. 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phospholipase C activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane]
Physical Entity
Activity
Inferred From
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