EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Stable Identifier
R-HSA-9032478
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate
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Phospholipase C gamma (PLCG1 or PLCG2) bound to the phosphorylated cytoplasmic domain of the EPO receptor (EPOR) hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to yield the second messengers diacylglycerol and 1D-myo-inositol 1,4,5-trisphosphate (Ren et al. 1994, and inferred from mouse). Erythropoietin may also activate the hydrolysis of phosphatidylcholine and phosphatidylethanolamine (inferred from mouse homologs),
Literature References
PubMed ID Title Journal Year
8034732 Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-gamma 1 in a human erythropoietin-dependent cell line

Ren, HY, Komatsu, N, Shimizu, R, Okada, K, Miura, Y

J. Biol. Chem. 1994
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Output
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as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate phospholipase C activity of EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane]

Physical Entity
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-PLCG1,2 [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate phospholipase C activity (GO:0004435)
Inferred From
Epor-associated Plcg hydrolyzes 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate (Mus musculus)
Authored
May, B  (2017-12-12)
Reviewed
McGraw, KL  (2018-08-14)
Created
May, B  (2017-12-13)
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