Reactome | I(1,4,5)P3 binds ITPR3 tetramer

I(1,4,5)P3 binds ITPR3 tetramer

Stable Identifier

R-HSA-9717214

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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One molecule of inositol 1,4,5-trisphosphate (I(1,4,5)P3) binds each subunit of IP3-gated calcium channel type 3 (ITPR3) causing the calcium permeable channel of ITPR3 to open and transport calcium ions from the lumen of the endoplasmic reticulum to the cytosol (Maranto 1994, Yoneshima et al. 1997, Paknejad and Hite 2018). The binding of calcium ions to ITPR3 decreases the affinity of ITPR3 for I(1,4,5)P3 (Yoneshima et al. 1997) and calcium bound to two cytosolic sites decreases the channel activity of ITPR3 (Paknejad and Hite 2018).

Literature References

PubMed ID	Title	Journal	Year
9065781	Ca2+ differentially regulates the ligand-affinity states of type 1 and type 3 inositol 1,4,5-trisphosphate receptors Yoneshima, H, Miyawaki, A, Michikawa, T, Furuichi, T, Mikoshiba, K	Biochem J	1997
8288584	Primary structure, ligand binding, and localization of the human type 3 inositol 1,4,5-trisphosphate receptor expressed in intestinal epithelium Maranto, AR	J Biol Chem	1994
30013099	Structural basis for the regulation of inositol trisphosphate receptors by Ca²⁺ and IP₃ Paknejad, N, Hite, RK	Nat Struct Mol Biol	2018