Hydrolysis of PIP2 by PLCG

Stable Identifier
R-HSA-2730847
Type
Reaction
Species
Homo sapiens
Compartment
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General
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Phosphoinositol 4,5-bisphosphate (PIP2) is cleaved in to two most important second messengers diacylglycerol (DAG) and Inositol 1,4,5-triphosphate (IP3) by phospholipase C (PLC). DAG remains within the membrane and activates protein kinase C (PKC) while IP3 leaves the cell membrane and binds to IP3 receptor that releases Ca2+ from endoplasmic reticulum (ER).

Literature References
PubMed ID Title Journal Year
11395409 Regulation of phosphoinositide-specific phospholipase C

Rhee, SG

Annu. Rev. Biochem. 2001
Participants
Participates
Catalyst Activity

phosphatidylinositol phospholipase C activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane]

Orthologous Events
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