Reactome | Hydrolysis of PIP2 by PLCG

Hydrolysis of PIP2 by PLCG

Stable Identifier

R-HSA-2730847

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphoinositol 4,5-bisphosphate (PIP2) is cleaved in to two most important second messengers diacylglycerol (DAG) and Inositol 1,4,5-triphosphate (IP3) by phospholipase C (PLC). DAG remains within the membrane and activates protein kinase C (PKC) while IP3 leaves the cell membrane and binds to IP3 receptor that releases Ca2+ from endoplasmic reticulum (ER).

Literature References

PubMed ID	Title	Journal	Year
11395409	Regulation of phosphoinositide-specific phospholipase C Rhee, SG	Annu. Rev. Biochem.	2001

Participants

Input

Output

Participates

as an event of

FCERI mediated Ca+2 mobilization (Homo sapiens)

Catalyst Activity

phosphatidylinositol phospholipase C activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane]

Physical Entity

p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)

Activity

phosphatidylinositol phospholipase C activity (GO:0004435)

Orthologous Events

Hydrolysis of PIP2 by PLCG (Bos taurus)

Hydrolysis of PIP2 by PLCG (Canis familiaris)

Hydrolysis of PIP2 by PLCG (Danio rerio)

Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)

Hydrolysis of PIP2 by PLCG (Gallus gallus)

Hydrolysis of PIP2 by PLCG (Mus musculus)

Hydrolysis of PIP2 by PLCG (Rattus norvegicus)