Hydrolysis of PIP2 by PLCG

Stable Identifier
R-HSA-2730847
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Hydrolysis of PIP2 by PLCG
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Phosphoinositol 4,5-bisphosphate (PIP2) is cleaved in to two most important second messengers diacylglycerol (DAG) and Inositol 1,4,5-triphosphate (IP3) by phospholipase C (PLC). DAG remains within the membrane and activates protein kinase C (PKC) while IP3 leaves the cell membrane and binds to IP3 receptor that releases Ca2+ from endoplasmic reticulum (ER).
Literature References
PubMed ID Title Journal Year
11395409 Regulation of phosphoinositide-specific phospholipase C

Rhee, SG

Annu. Rev. Biochem. 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane]

Physical Entity
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate phospholipase C activity (GO:0004435)
Orthologous Events
Hydrolysis of PIP2 by PLCG (Bos taurus)
Hydrolysis of PIP2 by PLCG (Canis familiaris)
Hydrolysis of PIP2 by PLCG (Drosophila melanogaster)
Hydrolysis of PIP2 by PLCG (Gallus gallus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
Hydrolysis of PIP2 by PLCG (Rattus norvegicus)
Hydrolysis of PIP2 by PLCG (Sus scrofa)
Hydrolysis of PIP2 by PLCG (Xenopus tropicalis)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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