Active PLCG1 hydrolyses PIP2

Stable Identifier
R-HSA-167686
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane, plasma membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active PLCG1 hydrolyses PIP2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-4Y-PLCG1 [plasma membrane]

Physical Entity
p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol-4,5-bisphosphate phospholipase C activity (GO:0004435)
Inferred From
Active Plcg1 hydrolyses PIP2 (Rattus norvegicus)
Cross References
RHEA
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
D'Eustachio, P  (2025-09-23)
Created
Jassal, B  (2005-11-01)
Cite Us!