p-Y753,Y759-PLCG2 hydrolyses PIP2

Stable Identifier
R-HSA-5607735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Following tyrosine phosphorylation, phospholipase C-gamma 2 (PLCG2) catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PIP2] to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).

Literature References
PubMed ID Title Journal Year
7612269 Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

Lee, SB, Rhee, SG

Curr. Opin. Cell Biol. 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phospholipase C activity of p-Y753,Y759-PLCG2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created