p-Y753,Y759-PLCG2 hydrolyses PIP2

Stable Identifier
R-HSA-5607735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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p-Y753,Y759-PLCG2 hydrolyses PIP2
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Following tyrosine phosphorylation, phospholipase C-gamma 2 (PLCG2) catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PIP2] to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).

Literature References
PubMed ID Title Journal Year
7612269 Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes

Lee, SB, Rhee, SG

Curr. Opin. Cell Biol. 1995
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phospholipase C activity of p-Y753,Y759-PLCG2 [plasma membrane]
Physical Entity
p-Y753,Y759-PLCG2 [plasma membrane]
Activity
phosphatidylinositol phospholipase C activity (0004435)
Orthologous Events
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Bos taurus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Caenorhabditis elegans)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Canis familiaris)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Danio rerio)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Dictyostelium discoideum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Drosophila melanogaster)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Gallus gallus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Mus musculus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Plasmodium falciparum)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Rattus norvegicus)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Saccharomyces cerevisiae)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Schizosaccharomyces pombe)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Sus scrofa)
p-Y753,Y759-PLCG2 hydrolyses PIP2 (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)