Following tyrosine phosphorylation, phospholipase C-gamma 2 (PLCG2) catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2 or PIP2] to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).
Lee, SB, Rhee, SG
phosphatidylinositol phospholipase C activity of p-Y753,Y759-PLCG2 [plasma membrane]
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