PLC gamma 2-mediated PIP2 hydrolysis

Stable Identifier
R-HSA-114689
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
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At the beginning of this reaction, 1 molecule of '1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate' is present. At the end of this reaction, 1 molecule of '1D-myo-Inositol 1,4,5-trisphosphate', and 1 molecule of '1,2-Diacylglycerol' are present.

This reaction is mediated by the 'phospholipase C activity' of 'Phosphorylated phospholipase C gamma 2'.

Literature References
PubMed ID Title Journal Year
2841328 Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets

Banno, Y, Yada, Y, Nozawa, Y

J Biol Chem 1988
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase C activity of p-PLCG2 [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Created