PIP2 hydrolysis

Stable Identifier
R-HSA-111879
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. One type, PLC-beta1, hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Literature References
PubMed ID Title Journal Year
11118617 Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)

Caricasole, A, Sala, C, Roncarati, R, Formenti, E, Terstappen, GC

Biochim Biophys Acta 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol phospholipase C activity of Activated PLC beta 1/4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created