Reactome | PIP2 hydrolysis

PIP2 hydrolysis

Stable Identifier

R-HSA-111879

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        PIP2 hydrolysis (Homo sapiens)

General

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The phospholipase C (PLC) family of enzymes is both diverse and complex. The isoforms beta, gamma and delta (each have subtypes) make up the members of this family. One type, PLC-beta1, hydrolyzes phosphatidylinositol bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mobilizes intracellular calcium stores while DAG activates protein kinase C isoforms which are involved in regulatory functions.

Literature References

PubMed ID	Title	Journal	Year
11118617	Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) Sala, C, Caricasole, A, Terstappen, GC, Roncarati, R, Formenti, E	Biochim Biophys Acta	2000