PIP2 hydrolysis

Stable Identifier
R-HSA-622382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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PIP2 hydrolysis
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PIP2 hydrolysis appers to be an important mechanism for netrin-1 mediated neurite elongation. Netrin-1 alone could not elicit hydrolysis of PIP2 but depends on the stimulation of DCC and PLCgamma.

Participants
Input
Output
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as an event of
Catalyst Activity

phosphatidylinositol phospholipase C activity of p-4Y-PLCG1 [plasma membrane]

Physical Entity
p-4Y-PLCG1 [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol phospholipase C activity (GO:0004435)
Inferred From
PIP2 hydrolysis (Rattus norvegicus)
Authored
Garapati, P V  (2010-04-23)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2010-04-23)
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