Reactome | Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

Stable Identifier

R-HSA-399998

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Synonyms

1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O => 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

ReviewStatus

5/5

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Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate

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Phospholipase C beta-1 associated with the G(q) complex in the plasma membrane catalyzes the hydrolysis of 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate to yield D-myo-Inositol 1,4,5-trisphosphate and 1,2-Diacylglycerol.

Literature References

PubMed ID	Title	Journal	Year
2841328	Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets Banno, Y, Yada, Y, Nozawa, Y	J Biol Chem	1988
11588141	Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function Gilon, P, Henquin, JC	Endocr Rev	2001