Active Plcg1 hydrolyses PIP2

Stable Identifier
R-RNO-182061
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active Plcg1 hydrolyses PIP2
Inositol 1,4,5-triphosphate (IP3) is a second messenger produced by phospholipase C (PLC) metabolism of phosphoinositol 4,5-bisphosphate (PIP2) (Canossa et al. 2001).
Literature References
PubMed ID Title Journal Year
11285228 Regulated secretion of neurotrophins by metabotropic glutamate group I (mGluRI) and Trk receptor activation is mediated via phospholipase C signalling pathways

Canossa, M, Gartner, A, Campana, G, Inagaki, N, Thoenen, H

EMBO J 2001
Participants
Input
Output
Catalyst Activity

phosphatidylinositol-4,5-bisphosphate phospholipase C activity of p-Plcg1 [plasma membrane]

Physical Entity
p-Plcg1 [plasma membrane] (Rattus norvegicus)
Activity
phosphatidylinositol-4,5-bisphosphate phospholipase C activity (GO:0004435)
Orthologous Events
Active PLCG1 hydrolyses PIP2 (Homo sapiens)
Authored
Jassal, B  (2006-07-06)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2006-07-06)
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