A group of phospholipase C proteins (“PLC(degh)”) bind to the plasma membrane via their PH domains. These phospholipases hydrolyse phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) to inositol 1,4,5 trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). The C2 domains of the enzymes bind to PI(4,5)P2 at the membrane.The phospholipase C isoforms involved and their corresponding literature references are: phosphoinositide phospholipase C delta-1(PLCD1) (Cheng et al. 1995); epsilon-1 (PLCE1) (Song et al. 2001, Lopez et al. 2001); delta-3 (PLCD3) (Pawelczyk & Matecki 1997); gamma-1 (PLCG1) (Harita et al. 2009, Baldassare et al. 1989); gamma-2 (PLCG2) (Banno et al. 1988); eta-1 (PLCH1) (Hwang et al. 2005); and eta-2 (PLCH2) (Zhou et al 2005).
Nozawa, Y, Yada, Y, Banno, Y
Suh, PG, Shin, KJ, Oh, YS, Ryu, SH, Kim, H, Hwang, JI
Matecki, A, Pawe?czyk, T
Wing, MR, Zhou, Y, Sondek, J, Harden, TK
Shibatohge, M, Satoh, T, Song, C, Kariyai, K, Hu, CD, Wu, D, Masago, M, Kataoka, T, Yamawaki-Kataoka, Y
Fisher, GJ, Henderson, PA, Baldassare, JJ
Kurihara, H, Igarashi, T, Harita, Y, Ohta, S, Tezuka, T, Hattori, S, Kosako, H, Ohsawa, I, Sekine, T
King, K, Chen, CL, Jiang, MJ, Cheng, HF, Wong, LP, Lomasney, JW, Liu, SM
Ding, J, Mak, EC, Hamm, HE, Lomasney, JW, Lopez, I
phosphatidylinositol phospholipase C activity of PLCdegh [plasma membrane]
© 2022 Reactome
