Reactome | PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane

Stable Identifier

R-HSA-1855221

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane

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A group of phospholipase C proteins (“PLC(degh)”) bind to the plasma membrane via their PH domains. These phospholipases hydrolyse phosphatidylinositol 4,5 bisphosphate (PI(4,5)P2) to inositol 1,4,5 trisphosphate (I(1,4,5)P3) and diacylglycerol (DAG). The C2 domains of the enzymes bind to PI(4,5)P2 at the membrane.

The phospholipase C isoforms involved and their corresponding literature references are: phosphoinositide phospholipase C delta-1(PLCD1) (Cheng et al. 1995); epsilon-1 (PLCE1) (Song et al. 2001, Lopez et al. 2001); delta-3 (PLCD3) (Pawelczyk & Matecki 1997); gamma-1 (PLCG1) (Harita et al. 2009, Baldassare et al. 1989); gamma-2 (PLCG2) (Banno et al. 1988); eta-1 (PLCH1) (Hwang et al. 2005); and eta-2 (PLCH2) (Zhou et al 2005).

Literature References

PubMed ID	Title	Journal	Year
2841328	Purification and characterization of membrane-bound phospholipase C specific for phosphoinositides from human platelets Nozawa, Y, Yada, Y, Banno, Y	J Biol Chem	1988
15702972	Molecular cloning and characterization of a novel phospholipase C, PLC-eta Suh, PG, Shin, KJ, Oh, YS, Ryu, SH, Kim, H, Hwang, JI	Biochem J	2005
9360711	Expression, purification and kinetic properties of human recombinant phospholipase C delta 3 Matecki, A, Pawe?czyk, T	Acta Biochim Pol	1997
16107206	Molecular cloning and characterization of PLC-eta2 Wing, MR, Zhou, Y, Sondek, J, Harden, TK	Biochem J	2005
11022048	Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras Shibatohge, M, Satoh, T, Song, C, Kariyai, K, Hu, CD, Wu, D, Masago, M, Kataoka, T, Yamawaki-Kataoka, Y	J Biol Chem	2001
2550068	Isolation and characterization of one soluble and two membrane-associated forms of phosphoinositide-specific phospholipase C from human platelets Fisher, GJ, Henderson, PA, Baldassare, JJ	Biochemistry	1989
19179337	Phosphorylation of Nephrin Triggers Ca2+ Signaling by Recruitment and Activation of Phospholipase C-{gamma}1 Kurihara, H, Igarashi, T, Harita, Y, Ohta, S, Tezuka, T, Hattori, S, Kosako, H, Ohsawa, I, Sekine, T	J Biol Chem	2009
7890667	Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis King, K, Chen, CL, Jiang, MJ, Cheng, HF, Wong, LP, Lomasney, JW, Liu, SM	J Biol Chem	1995
11022047	A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway Ding, J, Mak, EC, Hamm, HE, Lomasney, JW, Lopez, I	J Biol Chem	2001