PIP2 hydrolysis

Stable Identifier
R-RNO-622387
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PIP2 hydrolysis
PIP2 hydrolysis appers to be an important mechanism for netrin-1 mediated neurite elongation. Netrin-1 alone could not elicit hydrolysis of PIP2 but depends on the stimulation of DCC and PLCgamma.
Literature References
PubMed ID Title Journal Year
16321979 DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation

Ren, XR, Xiong, WC, Xie, Y, Mei, L, Hong, Y, Ackerman, S, Ma, XY

J Biol Chem 2006
Participants
Input
Output
Catalyst Activity

phosphatidylinositol phospholipase C activity of p-Plcg1 [plasma membrane]

Physical Entity
p-Plcg1 [plasma membrane] (Rattus norvegicus)
Activity
phosphatidylinositol phospholipase C activity (GO:0004435)
Orthologous Events
PIP2 hydrolysis (Homo sapiens)
Authored
Garapati, P V  (2010-04-13)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2010-04-23)
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