GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

Stable Identifier
R-HSA-9717205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG
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The binding of the gustducin beta-gamma complex (GNB1,3:GNG13) to Phospholipase C beta-2 (PLCB2) activates its catalytic activity, resulting in hydrolysis of phosphoinositol 4,5-bisphosphate (PI(4,5)P2) to yield diacylglycerol and inositol 1,4,5-trisphosphate (I(1,4,5)P3) (inferred from mouse, rat, and bovine homologs).
Participants
Input
Output
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as an event of
Catalyst Activity

phosphatidylinositol phospholipase C activity of GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane]

Physical Entity
GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane] (Homo sapiens)
Activity
phosphatidylinositol phospholipase C activity (GO:0004435)
Inferred From
Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Bos taurus)
Cross References
Rhea
Authored
May, B  (2021-03-05)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-08)
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