GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

Stable Identifier
R-HSA-9717205
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The binding of the gustducin beta-gamma complex (GNB1,3:GNG13) to Phospholipase C beta-2 (PLCB2) activates its catalytic activity, resulting in hydrolysis of phosphoinositol 4,5-bisphosphate (PI(4,5)P2) to yield diacylglycerol and inositol 1,4,5-trisphosphate (I(1,4,5)P3) (inferred from mouse, rat, and bovine homologs).

Participants
Participates
Catalyst Activity

phosphatidylinositol phospholipase C activity of GNB1,3:GNG13:PLCB2:Ca2+ [plasma membrane]

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