Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

Stable Identifier
R-NUL-9717576
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

The binding of the gustducin beta-gamma complex (Gnb1,3:GNG13) to Phospholipase beta-2 (PLCB2) activates its catalytic activity, resulting in hydrolysis of phosphoinositol 4,5-bisphosphate (PI(4,5)P2) to yield diacylglycerol and inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Romoser et al. 1996, Sankaran et al. 1998, Fogg et al. 2001, Yoshikawa et al. 2001, Bonacci et al. 2005).

Participants
Catalyst Activity

phosphatidylinositol phospholipase C activity of Gnb1:GNG2:PLCB2:Ca2+ [plasma membrane]

Orthologous Events
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