Reactome | C3b alpha' [extracellular region]

C3b alpha' [extracellular region]

Stable Identifier

R-HSA-166830

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C3(749-1663)

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01024 C3

Gene Names

C3, CPAMD1

Chain

signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663

Reference Genes

BioGPS Gene:718 C3

COSMIC (genes):C3 C3

CTD Gene:718 C3

dbSNP Gene:718 C3

ENSEMBL:ENSG00000125730 C3

HGNC:1318 C3

KEGG Gene (Homo sapiens):718 C3

Monarch:718 C3

NCBI Gene:718 C3

OMIM:120700 C3

Reference Transcript

RefSeq:NM_000064.3 C3

Other Identifiers

0006650731

11715393_a_at

16867784

217767_at

3848040

3848041

3848043

3848044

3848045

3848047

3848049

3848051

3848052

3848055

3848057

3848059

3848061

3848065

3848066

3848068

3848072

3848074

3848075

3848076

3848077

3848078

3848080

3848082

3848083

3848084

3848085

3848088

3848089

3848090

3848092

3848093

3848095

3848096

3848097

3848098

3848099

3848100

3848101

3848102

3848104

3848105

3848106

3848107

3848108

718

8033257

A_23_P101407

A_33_P3347869

GE61301

GO:0001798

GO:0001934

GO:0001970

GO:0002376

GO:0003674

GO:0004866

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0005886

GO:0006464

GO:0006629

GO:0006631

GO:0006810

GO:0006950

GO:0006954

GO:0006955

GO:0006956

GO:0006957

GO:0006958

GO:0007165

GO:0007186

GO:0007267

GO:0008150

GO:0009058

GO:0009617

GO:0009986

GO:0010575

GO:0010828

GO:0010866

GO:0010884

GO:0010951

GO:0016192

GO:0016322

GO:0021700

GO:0030154

GO:0030234

GO:0030449

GO:0031410

GO:0031715

GO:0032991

GO:0034330

GO:0034774

GO:0035578

GO:0043226

GO:0043312

GO:0043687

GO:0044267

GO:0044281

GO:0045087

GO:0045745

GO:0045766

GO:0048260

GO:0048646

GO:0048856

GO:0050766

GO:0050776

GO:0055085

GO:0060100

GO:0061024

GO:0070062

GO:0072562

GO:0097242

GO:0097278

GO:0150062

GO:0150064

GO:1905114

GO:2000427

ILMN_1662523

ILMN_1713182

ILMN_1762260

ILMN_1804151

K02765_at

PH_hs_0014742

TC19001103.hg

g4557384_3p_at

Participant Of

hasComponent

C3b [extracellular region]

Other forms of this molecule

C3d fragment [extracellular region]

C3c alpha' chain fragment 1 precursor [extracellular region]

C3c alpha' chain fragment 2 [extracellular region]

C3c alpha' chain fragment 1 [extracellular region]

C3a-desArg [extracellular region]

C3dg [plasma membrane]

C3d [plasma membrane]

C3f [extracellular region]

C3 beta chain [plasma membrane]

C3c alpha' chain fragment 1 precursor [plasma membrane]

C3c alpha' chain fragment 2 [plasma membrane]

C3 alpha chain [azurophil granule lumen]

C3 beta chain [azurophil granule lumen]

C3 alpha chain [secretory granule lumen]

C3 beta chain [secretory granule lumen]

p-C3 [endoplasmic reticulum lumen]

C3 [endoplasmic reticulum lumen]

C3 alpha chain [extracellular region]

dNQ-C3(672-1663) [extracellular region]

C3 beta chain [extracellular region]

C3a [extracellular region]

Inferred To

sema6a [extracellular region] (Xenopus tropicalis)

C3 [extracellular region] (Gallus gallus)

C3 [extracellular region] (Mus musculus)

C3 [extracellular region] (Rattus norvegicus)

Tep4 [extracellular region] (Drosophila melanogaster)

Homologues of C3b alpha' [extracellular region] (Caenorhabditis elegans)

Homologues of C3b alpha' [extracellular region] (Drosophila melanogaster)

Mcr [extracellular region] (Drosophila melanogaster)

Tep2 [extracellular region] (Drosophila melanogaster)

C3b alpha' [extracellular region] (Caenorhabditis elegans)

C3b alpha' [extracellular region] (Canis familiaris)

C3b alpha' [extracellular region] (Drosophila melanogaster)

Tep1 [extracellular region] (Drosophila melanogaster)

Tep3 [extracellular region] (Drosophila melanogaster)

c3b.1 [extracellular region] (Danio rerio)

tep-1 [extracellular region] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000055.2

OpenTargets

ENSG00000125730

HPA

ENSG00000125730-C3

GeneCards

P01024

Ensembl

ENST00000245907, ENSP00000245907, ENSG00000125730

ZINC target

P01024

PRO

P01024

Orphanet

17446

PDB

3OED, 2WII, 3T4A, 3NMS, 5FO7, 3D5R, 1W2S, 2XWB, 1C3D, 5O35, 3OHX, 4M76, 2QKI, 5O32, 2WY8, 6EHG, 2NOJ, 4I6O, 2ICF, 3OXU, 2WY7, 4ONT, 6RUV, 3G6J, 2ICE, 5NBQ, 2GOX, 4HWJ, 6RUR, 1GHQ, 6S0B, 5FOB, 4ZH1, 2XQW, 5FOA, 3RJ3, 3L3O, 2A74, 3L5N, 2XWJ, 2WIN, 5FO9, 3D5S, 4HW5, 2I07, 5FO8, 2A73

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-12735745 C3B			0.801	12
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.743	6
UniProt:P15529 CD46	1	CD46 [plasma membrane] (R-HSA-977362)	0.623	2
UniProt:Q92496-1 CFHR4			0.609	5
UniProt:Q9Y279-1 VSIG4			0.591	5
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q9Y279-2 VSIG4			0.524	2

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