Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
C3 beta chain
Stable Identifier
R-HSA-6799159
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
C3(23-667)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
C3 beta chain [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01024 C3
Gene Names
C3, CPAMD1
Chain
signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663
Reference Genes
BioGPS Gene:718 C3
COSMIC (genes):C3 C3
CTD Gene:718 C3
dbSNP Gene:718 C3
ENSEMBL:ENSG00000125730 C3
HGNC:1318 C3
KEGG Gene (Homo sapiens):hsa:718 C3
Monarch:718 C3
NCBI Gene:718 C3
OMIM:120700 C3
Reference Transcript
RefSeq:NM_000064.3 C3
Other Identifiers
0006650731
11715393_a_at
16867784
1C3D
1GHQ
1W2S
20432
217767_at
2A73
2A74
2I07
2ICE
2ICF
2NOJ
2QKI
2WII
2WIN
2WY7
2WY8
2XQW
2XWB
2XWJ
3563
3D5R
3D5S
3G6J
3L3O
3L5N
3NMS
3OED
3OHX
3OXU
3RJ3
3T4A
4209
4HW5
4HWJ
4I6O
4M76
4ONT
4ZH1
5FO7
5FO8
5FO9
5FOA
5FOB
5M6W
718
8033257
A_23_P101407
A_33_P3347869
AAA85332
AAI50180
AAI50201
AAR89906
ACJ13656
AY513239
BC150179
BC150200
C3
C3-201
CAB004209
CCDS32883
CH471139
EAW69071
ENSG00000125730
ENSP00000245907
ENST00000245907
EntrezGene:718
EU794602
g4557384_3p_at
GE61301
GO:0001798
GO:0001934
GO:0001970
GO:0002376
GO:0004252
GO:0004866
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005886
GO:0006508
GO:0006629
GO:0006631
GO:0006911
GO:0006954
GO:0006955
GO:0006956
GO:0006957
GO:0006958
GO:0007165
GO:0007186
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0010951
GO:0030449
GO:0031715
GO:0034774
GO:0035578
GO:0043234
GO:0043312
GO:0043687
GO:0044267
GO:0045087
GO:0045745
GO:0045766
GO:0050766
GO:0050776
GO:0070062
GO:0072562
GO:0097242
GO:2000427
HGNC:1318
HPA003563
HPA020432
Hs.529053
ILMN_1662523
ILMN_1713182
ILMN_1762260
ILMN_1804151
IPR000020
IPR001134
IPR001599
IPR001840
IPR002890
IPR008930
IPR008993
IPR009048
IPR011625
IPR011626
IPR018081
IPR018933
IPR019565
IPR019742
K02765
K02765_at
LRG_27
MIM:120700
MIM:611378
MIM:612925
MIM:613779
NM_000064
NP_000055
PF00207
PF01759
PF01821
PF01835
PF07677
PF07678
PF07703
PF10569
PH_hs_0014742
PR00004
SM00104
SM00643
SM01359
SM01360
SM01361
TC19001103.hg
uc002mfm.4
UPI000013EC9B
V9HWA9
Participant Of
hasMember
Azurophil granule lumen proteins [azurophil granule lumen]
Other forms of this molecule
C3d fragment [extracellular region]
p-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3c alpha' chain fragment 1 precursor [extracellular region]
C3c alpha' chain fragment 2 [extracellular region]
C3c alpha' chain fragment 1 [extracellular region]
C3a-desArg [extracellular region]
C3dg [plasma membrane]
C3d [plasma membrane]
C3f [extracellular region]
C3 beta chain [plasma membrane]
C3c alpha' chain fragment 1 precursor [plasma membrane]
C3c alpha' chain fragment 2 [plasma membrane]
C3 alpha chain [secretory granule lumen]
C3 beta chain [secretory granule lumen]
C3 alpha chain [azurophil granule lumen]
dNQ-C3(672-1663) [extracellular region]
C3 alpha chain [extracellular region]
C3b alpha' [extracellular region]
C3 beta chain [extracellular region]
C3a [extracellular region]
Inferred To
C3 beta chain [azurophil granule lumen] (Bos taurus)
C3 beta chain [azurophil granule lumen] (Canis familiaris)
C3 beta chain [azurophil granule lumen] (Danio rerio)
C3 beta chain [azurophil granule lumen] (Drosophila melanogaster)
C3 beta chain [azurophil granule lumen] (Gallus gallus)
C3 beta chain [azurophil granule lumen] (Mus musculus)
C3 beta chain [azurophil granule lumen] (Rattus norvegicus)
C3 beta chain [azurophil granule lumen] (Sus scrofa)
C3 beta chain [azurophil granule lumen] (Xenopus tropicalis)
Homologues of C3 beta chain [azurophil granule lumen] (Canis familiaris)
Homologues of C3 beta chain [azurophil granule lumen] (Danio rerio)
Homologues of C3 beta chain [azurophil granule lumen] (Drosophila melanogaster)
Homologues of C3 beta chain [azurophil granule lumen] (Gallus gallus)
Homologues of C3 beta chain [azurophil granule lumen] (Rattus norvegicus)
Homologues of C3 beta chain [azurophil granule lumen] (Sus scrofa)
Homologues of C3 beta chain [azurophil granule lumen] (Xenopus tropicalis)
Cross References
RefSeq
NP_000055.2
Brenda
3.4.21.47
GeneCards
P01024
DOCK Blaster
4HW5
,
3T4A
,
3OED
,
4ZH1
,
3D5R
,
3D5S
,
3L5N
,
4ONT
,
2WIN
,
2QKI
,
3OHX
,
2WII
,
4I6O
,
3G6J
,
3NMS
,
5FOA
,
2XQW
,
5FOB
,
3RJ3
,
2NOJ
,
5M6W
,
2WY8
,
2WY7
,
2ICF
,
2ICE
,
2XWB
,
2GOX
,
4M76
,
3L3O
,
4HWJ
,
2XWJ
,
5FO8
,
5FO9
,
5FO7
,
2I07
,
2A74
,
2A73
,
3OXU
,
1C3D
,
1GHQ
ZINC target
P01024
PRO
P01024
Orphanet
17446
PDB
2ICE
,
5FOB
,
5M6W
,
2ICF
,
5NBQ
,
2NOJ
,
5O32
,
2QKI
,
5O35
,
2WII
,
2WIN
,
2WY7
,
2WY8
,
4I6O
,
4M76
,
1C3D
,
4ONT
,
1GHQ
,
4ZH1
,
1W2S
,
5FO7
,
2A73
,
5FO8
,
2A74
,
5FO9
,
2GOX
,
5FOA
,
2I07
,
3NMS
,
3OED
,
3OHX
,
3OXU
,
3L5N
,
3L3O
,
3G6J
,
3D5S
,
3D5R
,
2XWJ
,
2XWB
,
2XQW
,
4HWJ
,
4HW5
,
3T4A
,
3RJ3
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.655
5
UniProt:Q9Y279-1 VSIG4
0.591
5
UniProt:Q9Y279-2 VSIG4
0.524
2
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.488
2
UniProt:A6NEM1 GG6L9
0.488
2
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.488
2
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.488
2
© 2018
Reactome