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EGLN3 [cytosol]
Stable Identifier
R-HSA-1234115
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Egl nine homolog 3, EGLN3_HUMAN, PHD3
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
Proteasome proteolyzes ub-HIF-alpha (Homo sapiens)
VBC complex (with or without LIMD1) [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VCB (with or without LIMD1) [cytosol] (Homo sapiens)
ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:CUL2:RBX1:LIMD1,AJUBA,WTIF:PHD2,3 [cytosol] (Homo sapiens)
PHD2,3:LIMD1,AJUBA,WTIP:VHL:EloB:EloC:CUL2:RBX1 [cytosol] (Homo sapiens)
PHD2,3 [cytosol] (Homo sapiens)
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
EGLN3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H6Z9 EGLN3
Gene Names
EGLN3
Chain
chain:1-239
Reference Genes
BioGPS Gene:112399 EGLN3
COSMIC (genes):EGLN3 EGLN3
CTD Gene:112399 EGLN3
dbSNP Gene:112399 EGLN3
ENSEMBL:ENSG00000129521 EGLN3
ENSEMBL_homo_sapiens_GENE:ENSG00000129521.15 EGLN3
HGNC:14661 EGLN3
KEGG Gene (Homo sapiens):112399 EGLN3
Monarch:112399 EGLN3
NCBI Gene:112399 EGLN3
OMIM:606426 EGLN3
UCSC:Q9H6Z9 EGLN3
Reference Transcript
RefSeq:NM_022073.3 EGLN3
RefSeq:NM_001308103.1 EGLN3
Other Identifiers
112399
11733852_at
11757444_a_at
219232_PM_s_at
219232_s_at
222847_PM_s_at
222847_s_at
3560413
3560414
3560415
3560416
3560417
3560418
3560419
3560421
3560422
3560423
3560437
3560438
3560439
3560440
3560441
3560442
3560443
3560444
3560445
60511_at
7978544
A_23_P360379
A_33_P3256952
GE56932
GO:0001666
GO:0003824
GO:0005506
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006915
GO:0006919
GO:0006974
GO:0008198
GO:0012501
GO:0016491
GO:0016705
GO:0016706
GO:0018126
GO:0018401
GO:0031418
GO:0031545
GO:0036211
GO:0042127
GO:0043226
GO:0043523
GO:0046872
GO:0051213
GO:0071456
GO:0140096
GO:0160082
HMNXSV003035924
Hs.18878.0.A1_3p_a_at
ILMN_1667626
PH_hs_0025932
TC14001022.hg
g11545786_3p_a_at
Participates
as a component of
EGLN3:AscH-:Fe2+ [cytosol] (Homo sapiens)
Other forms of this molecule
EGLN3 [nucleoplasm]
Inferred To
EGLN3 [cytosol]
(Bos taurus)
EGLN3 [cytosol]
(Caenorhabditis elegans)
EGLN3 [cytosol]
(Canis familiaris)
EGLN3 [cytosol]
(Gallus gallus)
EGLN3 [cytosol]
(Mus musculus)
EGLN3 [cytosol]
(Rattus norvegicus)
EGLN3 [cytosol]
(Sus scrofa)
egln3 [cytosol]
(Xenopus tropicalis)
Hph [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001295032.1
,
NP_071356.1
Guide to Pharmacology - Targets
2834
OpenTargets
ENSG00000129521
GeneCards
Q9H6Z9
ZINC - Substances
EGLN3_HUMAN
HPA
ENSG00000129521-EGLN3
ZINC target
Q9H6Z9
Ensembl
ENSG00000129521
,
ENST00000250457
,
ENSP00000250457
PRO
Q9H6Z9
Pharos - Targets
Q9H6Z9
ZINC - Predictions - Purchasable
EGLN3_HUMAN
HMDB Protein
HMDBP09212
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16665 HIF1A
7
HN-HIF1A [cytosol]
(R-HSA-1234110)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
HIF1A [cytosol]
(R-HSA-1234102)
HIF1A [nucleoplasm]
(R-HSA-1234135)
0.881
7
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.681
6
UniProt:Q13123 IK
1
IK [nucleoplasm]
(R-HSA-9770239)
0.556
3
UniProt:Q13085 ACACA
2
ACACA [cytosol]
(R-HSA-1660609)
Btn-ACACA [cytosol]
(R-HSA-2976730)
0.527
2
UniProt:P14618-1 PKM
2
PolyUb-PKM-1 [cytosol]
(R-HSA-9861692)
PKM-1 [cytosol]
(R-HSA-71667)
0.524
2
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