C3 alpha chain [extracellular region]

Stable Identifier
R-HSA-166820
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
S-(L-isoglutamyl)-L-cysteine-C3(672-1663)
Icon
C3 alpha chain [extracellular region] icon
C3 alpha chain [extracellular region] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P01024 C3
Gene Names
C3, CPAMD1
Chain
signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663
Reference Genes
BioGPS Gene:718 C3
COSMIC (genes):C3 C3
CTD Gene:718 C3
dbSNP Gene:718 C3
ENSEMBL:ENSG00000125730.18 C3
HGNC:1318 C3
KEGG Gene (Homo sapiens):718 C3
Monarch:718 C3
NCBI Gene:718 C3
OMIM:120700 C3
Reference Transcript
Other Identifiers
11715393_a_at
16867784
217767_PM_at
217767_at
3848040
3848041
3848043
3848044
3848045
3848047
3848049
3848051
3848052
3848055
3848057
3848059
3848061
3848065
3848066
3848068
3848072
3848074
3848075
3848076
3848077
3848078
3848080
3848082
3848083
3848084
3848085
3848088
3848089
3848090
3848092
3848093
3848095
3848096
3848097
3848098
3848099
3848100
3848101
3848102
3848104
3848105
3848106
3848107
3848108
718
8033257
A_33_P3347869
GE61301
GO:0001798
GO:0001934
GO:0001970
GO:0002376
GO:0004866
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005886
GO:0006629
GO:0006631
GO:0006954
GO:0006955
GO:0006956
GO:0006957
GO:0006958
GO:0007165
GO:0007186
GO:0009617
GO:0009986
GO:0010575
GO:0010828
GO:0010866
GO:0010884
GO:0016192
GO:0016322
GO:0022414
GO:0023052
GO:0030154
GO:0031410
GO:0031715
GO:0032991
GO:0034330
GO:0034774
GO:0035578
GO:0035846
GO:0036211
GO:0043226
GO:0045087
GO:0045745
GO:0045766
GO:0048260
GO:0048584
GO:0048856
GO:0050766
GO:0055085
GO:0060100
GO:0061024
GO:0070062
GO:0072562
GO:0097242
GO:0097278
GO:0098542
GO:0098772
GO:0150062
GO:0150064
GO:1905114
GO:2000427
ILMN_1662523
K02765_at
PH_hs_0014742
TC19001103.hg
g4557384_3p_at
Participates
as a member of
as a component of
Other forms of this molecule
C3d fragment [extracellular region]
p-C3 [endoplasmic reticulum lumen]
C3 [endoplasmic reticulum lumen]
C3 alpha chain [azurophil granule lumen]
C3 beta chain [azurophil granule lumen]
C3 alpha chain [secretory granule lumen]
C3 beta chain [secretory granule lumen]
C3c alpha' chain fragment 1 precursor [extracellular region]
C3c alpha' chain fragment 2 [extracellular region]
C3c alpha' chain fragment 1 [extracellular region]
C3a-desArg [extracellular region]
C3dg [plasma membrane]
C3d [plasma membrane]
C3f [extracellular region]
C3 beta chain [plasma membrane]
C3c alpha' chain fragment 1 precursor [plasma membrane]
C3c alpha' chain fragment 2 [plasma membrane]
C3b alpha' [extracellular region]
C3 beta chain [extracellular region]
dNQ-C3(672-1663) [extracellular region]
C3a [extracellular region]
Inferred To
Homologues of C3 alpha chain [extracellular region] (Caenorhabditis elegans)
Homologues of C3 alpha chain [extracellular region] (Drosophila melanogaster)
C3 [extracellular region] (Bos taurus)
C3 [extracellular region] (Mus musculus)
C3 [extracellular region] (Rattus norvegicus)
C3 [extracellular region] (Sus scrofa)
Tep4 [extracellular region] (Drosophila melanogaster)
C3 alpha chain [extracellular region] (Caenorhabditis elegans)
C3 alpha chain [extracellular region] (Canis familiaris)
C3 alpha chain [extracellular region] (Danio rerio)
C3 alpha chain [extracellular region] (Gallus gallus)
Mcr [extracellular region] (Drosophila melanogaster)
Tep2 [extracellular region] (Drosophila melanogaster)
Tep1 [extracellular region] (Drosophila melanogaster)
Tep3 [extracellular region] (Drosophila melanogaster)
c3 [extracellular region] (Xenopus tropicalis)
tep-1 [extracellular region] (Caenorhabditis elegans)
Modified Residues
Name
Intra-chain Crosslink via S-(L-isoglutamyl)-L-cysteine at 1010 and 1013
Coordinate
1010
PsiMod Name
S-(L-isoglutamyl)-L-cysteine
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia.
Cross References
RefSeq
OpenTargets
HPA
GeneCards
ZINC target
Ensembl
PRO
Pharos - Targets
Orphanet
PDB
Interactors (14)
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