Reactome | C3 alpha chain [extracellular region]

C3 alpha chain [extracellular region]

Stable Identifier

R-HSA-166820

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

S-(L-isoglutamyl)-L-cysteine-C3(672-1663)

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01024 C3

Gene Names

C3, CPAMD1

Chain

signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663

Reference Genes

BioGPS Gene:718 C3

COSMIC (genes):C3 C3

CTD Gene:718 C3

dbSNP Gene:718 C3

ENSEMBL:ENSG00000125730 C3

HGNC:1318 C3

KEGG:hsa:718 C3

Monarch:718 C3

NCBI Gene:718 C3

OMIM:120700 C3

UCSC:P01024 C3

Reference Transcript

RefSeq:NM_000064.3 C3

Participates

as a member of

as a component of

Complement factor 3 [extracellular region] (Homo sapiens)

Other forms of this molecule

C3a [extracellular region]

dNQ-C3(672-1663) [extracellular region]

C3 beta chain [extracellular region]

C3b alpha' [extracellular region]

C3c alpha' chain fragment 2 [plasma membrane]

C3c alpha' chain fragment 1 precursor [plasma membrane]

C3 beta chain [plasma membrane]

C3f [extracellular region]

C3d [plasma membrane]

C3dg [plasma membrane]

C3a-desArg [extracellular region]

C3c alpha' chain fragment 1 [extracellular region]

C3c alpha' chain fragment 2 [extracellular region]

C3c alpha' chain fragment 1 precursor [extracellular region]

C3 [endoplasmic reticulum lumen]

p-C3 [endoplasmic reticulum lumen]

C3 beta chain [secretory granule lumen]

C3 alpha chain [secretory granule lumen]

C3 beta chain [azurophil granule lumen]

C3 alpha chain [azurophil granule lumen]

C3d fragment [extracellular region]

Inferred To

Homologues of C3 alpha chain [extracellular region] (Xenopus tropicalis)

LOC100491968 [extracellular region] (Xenopus tropicalis)

C3 [extracellular region] (Bos taurus)

C3 [extracellular region] (Canis familiaris)

C3 [extracellular region] (Mus musculus)

C3 [extracellular region] (Rattus norvegicus)

C3 [extracellular region] (Sus scrofa)

c3a.2 [extracellular region] (Danio rerio)

LOC100170611 [extracellular region] (Xenopus tropicalis)

C3 alpha chain [extracellular region] (Gallus gallus)

Modified Residues

Name

Intra-chain Crosslink via S-(L-isoglutamyl)-L-cysteine at 1010 and 1013

Coordinate

1010

PsiMod Name

S-(L-isoglutamyl)-L-cysteine

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia.

Cross References

RefSeq

NP_000055.2

OpenTargets

ENSG00000125730

ENSEMBL

ENST00000245907, ENSP00000245907, ENSG00000125730

GeneCards

HPA

ENSG00000125730-C3

ZINC - Substances

CO3_HUMAN

ZINC target

P01024

PRO

P01024

Pharos - Targets

P01024

GlyGen

P01024

Orphanet

PDB

4ZH1, 5O32, 2XQW, 3NMS, 6RMT, 8I9L, 4HWJ, 3D5R, 6RUR, 2I07, 5FO9, 5O35, 3RJ3, 2A74, 8UH2, 2WII, 2QKI, 8HK2, 2ICF, 6RUV, 5NBQ, 5FOA, 7AKK, 4HW5, 7QIV, 4M76, 4I6O, 2WY7, 8EOK, 7NOZ, 3L3O, 2XWJ, 6EHG, 3OHX, 8ENU, 1GHQ, 7TV9, 3OED, 8OVB, 6RMU, 7UE9, 3L5N, 3OXU, 3D5S, 2A73, 6YO6, 3T4A, 2WIN, 2GOX, 2ICE, 8OQ3, 3G6J, 1C3D, 5FOB, 7BAG, 7PI6, 7ZGK, 2WY8, 5FO7, 8UIN, 6S0B, 5FO8, 1W2S, 4ONT, 2NOJ, 2XWB

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-12735745 C3B			0.801	12
UniProt:P08603 CFH	1	CFH [extracellular region] (R-HSA-976788)	0.743	6
UniProt:P20023 CR2	1	CR2 [plasma membrane] (R-HSA-197936)	0.719	4
UniProt:P15529 CD46	1	CD46 [plasma membrane] (R-HSA-977362)	0.623	2
UniProt:O60741 HCN1	1	HCN1 [plasma membrane] (R-HSA-977503)	0.623	7
UniProt:Q92496-1 CFHR4			0.609	5
UniProt:Q9Y279-1 VSIG4			0.591	5
ChEBI:28304 HEPARIN			0.589	2
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q9H8H2 DDX31			0.527	2
UniProt:P35219 CAH8			0.527	2
UniProt:Q9Y279-2 VSIG4			0.524	2
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.499	2

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