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C3 alpha chain [extracellular region]
Stable Identifier
R-HSA-166820
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
S-(L-isoglutamyl)-L-cysteine-C3(672-1663)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Cleavage of C3 by C3 convertases (Homo sapiens)
Complement factor 3 [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
C3(H2O):Factor Bb cleaves C3 to C3b and C3a (Homo sapiens)
Complement factor 3 [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
Formation of alternative pathway C5 convertase (Homo sapiens)
Complement factor 3 [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
Spontaneous hydrolysis of C3 thioester (Homo sapiens)
Complement factor 3 [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
C3 alpha chain [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01024 C3
Gene Names
C3, CPAMD1
Chain
signal peptide:1-22, chain:23-1663, chain:23-667, chain:569-667, chain:672-1663, chain:672-748, chain:672-747, chain:749-1663, chain:749-954, chain:955-1303, chain:955-1001, chain:1002-1303, peptide:1304-1320, chain:1321-1663
Reference Genes
BioGPS Gene:718 C3
COSMIC (genes):C3 C3
CTD Gene:718 C3
dbSNP Gene:718 C3
ENSEMBL:ENSG00000125730 C3
HGNC:1318 C3
KEGG:hsa:718 C3
Monarch:718 C3
NCBI Gene:718 C3
OMIM:120700 C3
UCSC:P01024 C3
Reference Transcript
RefSeq:NM_000064.3 C3
Participates
as a member of
Azurophil granule lumen proteins [extracellular region] (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
Complement factor 3 [extracellular region] (Homo sapiens)
Other forms of this molecule
C3a [extracellular region]
dNQ-C3(672-1663) [extracellular region]
C3 beta chain [extracellular region]
C3b alpha' [extracellular region]
C3c alpha' chain fragment 2 [plasma membrane]
C3c alpha' chain fragment 1 precursor [plasma membrane]
C3 beta chain [plasma membrane]
C3f [extracellular region]
C3d [plasma membrane]
C3dg [plasma membrane]
C3a-desArg [extracellular region]
C3c alpha' chain fragment 1 [extracellular region]
C3c alpha' chain fragment 2 [extracellular region]
C3c alpha' chain fragment 1 precursor [extracellular region]
C3 [endoplasmic reticulum lumen]
p-C3 [endoplasmic reticulum lumen]
C3 beta chain [secretory granule lumen]
C3 alpha chain [secretory granule lumen]
C3 beta chain [azurophil granule lumen]
C3 alpha chain [azurophil granule lumen]
C3d fragment [extracellular region]
Inferred To
Homologues of C3 alpha chain [extracellular region]
(Xenopus tropicalis)
LOC100491968 [extracellular region]
(Xenopus tropicalis)
C3 [extracellular region]
(Bos taurus)
C3 [extracellular region]
(Canis familiaris)
C3 [extracellular region]
(Mus musculus)
C3 [extracellular region]
(Rattus norvegicus)
C3 [extracellular region]
(Sus scrofa)
c3a.2 [extracellular region]
(Danio rerio)
LOC100170611 [extracellular region]
(Xenopus tropicalis)
C3 alpha chain [extracellular region]
(Gallus gallus)
Modified Residues
Name
Intra-chain Crosslink via S-(L-isoglutamyl)-L-cysteine at 1010 and 1013
Coordinate
1010
PsiMod Name
S-(L-isoglutamyl)-L-cysteine
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and an L-glutamine residue by a thioester bond with the formation of S-(L-isoglutamyl)-L-cysteine and the release of ammonia.
Cross References
RefSeq
NP_000055.2
OpenTargets
ENSG00000125730
ENSEMBL
ENST00000245907
,
ENSP00000245907
,
ENSG00000125730
GeneCards
C3
HPA
ENSG00000125730-C3
ZINC - Substances
CO3_HUMAN
ZINC target
P01024
PRO
P01024
Pharos - Targets
P01024
GlyGen
P01024
Orphanet
C3
PDB
4ZH1
,
5O32
,
2XQW
,
3NMS
,
6RMT
,
8I9L
,
4HWJ
,
3D5R
,
6RUR
,
2I07
,
5FO9
,
5O35
,
3RJ3
,
2A74
,
8UH2
,
2WII
,
2QKI
,
8HK2
,
2ICF
,
6RUV
,
5NBQ
,
5FOA
,
7AKK
,
4HW5
,
7QIV
,
4M76
,
4I6O
,
2WY7
,
8EOK
,
7NOZ
,
3L3O
,
2XWJ
,
6EHG
,
3OHX
,
8ENU
,
1GHQ
,
7TV9
,
3OED
,
8OVB
,
6RMU
,
7UE9
,
3L5N
,
3OXU
,
3D5S
,
2A73
,
6YO6
,
3T4A
,
2WIN
,
2GOX
,
2ICE
,
8OQ3
,
3G6J
,
1C3D
,
5FOB
,
7BAG
,
7PI6
,
7ZGK
,
2WY8
,
5FO7
,
8UIN
,
6S0B
,
5FO8
,
1W2S
,
4ONT
,
2NOJ
,
2XWB
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-12735745 C3B
0.801
12
UniProt:P08603 CFH
1
CFH [extracellular region]
(R-HSA-976788)
0.743
6
UniProt:P20023 CR2
1
CR2 [plasma membrane]
(R-HSA-197936)
0.719
4
UniProt:P15529 CD46
1
CD46 [plasma membrane]
(R-HSA-977362)
0.623
2
UniProt:O60741 HCN1
1
HCN1 [plasma membrane]
(R-HSA-977503)
0.623
7
UniProt:Q92496-1 CFHR4
0.609
5
UniProt:Q9Y279-1 VSIG4
0.591
5
ChEBI:28304 HEPARIN
0.589
2
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:A6NEM1 GG6L9
0.556
3
UniProt:O95967 EFEMP2
1
EFEMP2 [extracellular region]
(R-HSA-2161231)
0.556
3
UniProt:O95994 AGR2
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q16659 MAPK6 gene
6
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
MAPK6 [cytosol]
(R-HSA-5686979)
ub-MAPK6 [cytosol]
(R-HSA-5687000)
0.527
2
UniProt:Q9H8H2 DDX31
0.527
2
UniProt:P35219 CAH8
0.527
2
UniProt:Q9Y279-2 VSIG4
0.524
2
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.499
2
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