Reactome | 5xHC-HP(162-406) [endocytic vesicle lumen]

5xHC-HP(162-406) [endocytic vesicle lumen]

Stable Identifier

R-HSA-2230973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endocytic vesicle lumen

Synonyms

HP beta chain, Haptoglobin beta chain, HPT_HUMAN, HP

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Homo sapiens)

- Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens)
  - Scavenging of heme from plasma (Homo sapiens)
    - Hemoglobin:Haptoglobin:CD163 is endocytosed (Homo sapiens)
      - Hemoglobin:Haptoglobin:CD163 [endocytic vesicle membrane] (Homo sapiens)
        
        Hemoglobin:Haptoglobin [endocytic vesicle lumen] (Homo sapiens)
        
        Haptoglobin Dimer [endocytic vesicle lumen] (Homo sapiens)
        
        Haptoglobin [endocytic vesicle lumen] (Homo sapiens)
        
        5xHC-HP(162-406) [endocytic vesicle lumen] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00738 HP

Gene Names

Chain

signal peptide:1-18, chain:19-406, chain:19-160, chain:162-406

Reference Genes

BioGPS Gene:3240 HP

COSMIC (genes):HP HP

CTD Gene:3240 HP

dbSNP Gene:3240 HP

ENSEMBL:ENSG00000257017 HP

ENSEMBL_homo_sapiens_GENE:ENSG00000257017.10 HP

HGNC:5141 HP

KEGG Gene (Homo sapiens):3240 HP

Monarch:3240 HP

NCBI Gene:3240 HP

OMIM:140100 HP

UCSC:P00738 HP

Reference Transcript

Other Identifiers

11733829_x_at

11744649_x_at

11757277_x_at

16820937

206697_3p_s_at

206697_PM_s_at

206697_s_at

208470_PM_s_at

208470_s_at

3240

3667859

3667865

3667868

3667870

3667871

3667874

3667875

3667877

3667878

3667879

3667880

3667881

3667882

3667883

3667884

3667885

3667895

3667899

36983_f_at

36984_f_at

7997188

A_23_P206760

A_33_P3289236

GE59631

GO:0002376

GO:0003824

GO:0004252

GO:0005515

GO:0005576

GO:0005615

GO:0006508

GO:0006952

GO:0006953

GO:0006954

GO:0016209

GO:0016787

GO:0030492

GO:0031410

GO:0031838

GO:0035580

GO:0042542

GO:0042742

GO:0043226

GO:0051354

GO:0070062

GO:0071682

GO:0072562

GO:0098542

GO:0098754

GO:0098869

GO:0140096

GO:1904724

GO:2000296

HMNXSV003047722

Hs2Affx.1.389.S1_3p_s_at

ILMN_1812433

K03431_cds1_at

M69197_xpt2_s_at

PH_hs_0030034

TC16002057.hg

g4826761_3p_s_at

g4826761_3p_x_at

Participates

as a component of

Haptoglobin [endocytic vesicle lumen] (Homo sapiens)

Other forms of this molecule

HP [specific granule lumen]

HP [extracellular region]

HP [tertiary granule lumen]

7xHC-HP(19-160) [endocytic vesicle lumen]

5xHC-HP(162-406) [extracellular region]

7xHC-HP(19-160) [extracellular region]

Inferred To

Hp [endocytic vesicle lumen] (Mus musculus)

Hp [endocytic vesicle lumen] (Rattus norvegicus)

5xHC-HP(162-406) [endocytic vesicle lumen] (Gallus gallus)

5xHC-HP(162-406) [endocytic vesicle lumen] (Sus scrofa)

Homologues of 5xHC-HP(162-406) [endocytic vesicle lumen] (Sus scrofa)

Ghost homologue of 5xHC-HP(162-406) [endocytic vesicle lumen] (Bos taurus)

Ghost homologue of 5xHC-HP(162-406) [endocytic vesicle lumen] (Canis familiaris)

c1s.2 [endocytic vesicle lumen] (Danio rerio)

HP [endocytic vesicle lumen] (Sus scrofa)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 309 and 340

Coordinate

309

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Intra-chain Crosslink via L-cystine (cross-link) at 351 and 381

Coordinate

351

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Name

Inter-chain Crosslink via L-cystine (cross-link) at 266 and 149

Coordinate

266

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_001119574.1, NP_005134.1, NP_001305067.1

OpenTargets

ENSG00000257017

HPA

ENSG00000257017-HP

GeneCards

P00738

Ensembl

ENST00000398131, ENST00000570083, ENSP00000457629, ENSG00000257017, ENSP00000348170, ENSP00000381199, ENST00000355906

PRO

P00738

Pharos - Targets

P00738

HMDB Protein

HMDBP02380

PDB

4WJG, 6TB2, 4X0L, 5HU6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.675	7
UniProt:P02647 APOA1	11	APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) APOA1(25-266) [extracellular region] (R-HSA-174720)	0.558	3
UniProt:Q16659 MAPK6 gene	6	ub-MAPK6 [cytosol] (R-HSA-5687000) MAPK6 [cytosol] (R-HSA-5686979) p-S189 MAPK6 [cytosol] (R-HSA-5687019) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) MAPK6 [nucleoplasm] (R-HSA-5692686) p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665)	0.527	2