Reactome | HS(6)-SDC2 [lysosomal lumen]

HS(6)-SDC2 [lysosomal lumen]

Stable Identifier

R-HSA-2090064

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

SDC2, HSPG, SDC2_HUMAN, Heparan sulfate proteoglycan core protein

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External Reference Information

External Reference

UniProt:P34741 SDC2

Gene Names

SDC2, HSPG1

Chain

signal peptide:1-18, chain:19-201

Reference Genes

BioGPS Gene:6383 SDC2

COSMIC (genes):SDC2 SDC2

CTD Gene:6383 SDC2

dbSNP Gene:6383 SDC2

ENSEMBL:ENSG00000169439 SDC2

ENSEMBL_homo_sapiens_GENE:ENSG00000169439.12 SDC2

HGNC:10659 SDC2

KEGG Gene (Homo sapiens):6383 SDC2

Monarch:6383 SDC2

NCBI Gene:6383 SDC2

OMIM:142460 SDC2

UCSC:P34741 SDC2

Reference Transcript

RefSeq:NM_002998.3 SDC2

Other Identifiers

11720753_s_at

11745006_a_at

11745007_s_at

11746797_a_at

11746798_x_at

11751122_x_at

17071144

212154_PM_at

212154_at

212157_PM_at

212157_at

212158_PM_at

212158_at

3108152

3108153

3108154

3108155

3108156

3108157

3108158

3108184

3108185

3108186

3108187

3108188

3108189

3108190

3108191

3108192

3108210

3108212

39757_at

6383

65000_at

8147461

A_14_P109550

A_24_P380734

A_33_P3371219

GE57514

GO:0005515

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0007399

GO:0008150

GO:0009986

GO:0016020

GO:0016477

GO:0030154

GO:0030165

GO:0030312

GO:0031012

GO:0042802

GO:0043202

GO:0043226

GO:0048813

GO:0048814

GO:0048856

GO:0048870

GO:0062023

HMNXSV003007453

Hs.1501.0.S1_3p_at

Hs.1501.0.S2_3p_at

Hs.1501.0.S3_3p_at

ILMN_1784553

J04621_at

PH_hs_0000201

TC08000590.hg

Participates

as a member of

HS/HPIN-PGs [lysosomal lumen] (Homo sapiens)

Other forms of this molecule

SDC2 [plasma membrane]

p-Y179,Y191-SDC2 [plasma membrane]

SDC2 [lysosomal lumen]

HS(1)-SDC2 [Golgi lumen]

HS(2)-SDC2 [Golgi lumen]

HS(3)-SDC2 [Golgi lumen]

HS(4)-SDC2 [Golgi lumen]

HS(6)-SDC2 [Golgi lumen]

HS(5)-SDC2 [Golgi lumen]

Heparan-SDC2 [Golgi lumen]

Heparan(1)-SDC2 [Golgi lumen]

Heparan(2)-SDC2 [Golgi lumen]

Heparan(4)-SDC2 [Golgi lumen]

Heparan(3)-SDC2 [Golgi lumen]

SDC2 [Golgi lumen]

HS(4)-SDC2 [plasma membrane]

HS(6)-SDC2 [plasma membrane]

HS(2)-SDC2 [plasma membrane]

HS(1)-SDC2 [plasma membrane]

HS(3)-SDC2 [plasma membrane]

HS(5)-SDC2 [plasma membrane]

SDC2 [endoplasmic reticulum lumen]

p-SDC2 [endoplasmic reticulum lumen]

Gal-Gal-Xyl-SDC2 [Golgi lumen]

GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]

Gal-Xyl-SDC2 [Golgi lumen]

XylS-SDC2 [Golgi lumen]

Inferred To

sdn-1 [lysosomal lumen] (Caenorhabditis elegans)

SDC2 [lysosomal lumen] (Bos taurus)

SDC2 [lysosomal lumen] (Gallus gallus)

SDC2 [lysosomal lumen] (Sus scrofa)

sdc2 [lysosomal lumen] (Danio rerio)

sdc2 [lysosomal lumen] (Xenopus tropicalis)

Sdc [lysosomal lumen] (Drosophila melanogaster)

Sdc2 [lysosomal lumen] (Mus musculus)

Sdc2 [lysosomal lumen] (Rattus norvegicus)

Modified Residues

Name

O-xylosyl-L-serine (ChEBI:63666) at unknown position

Modification

beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

NP_002989.2

OpenTargets

ENSG00000169439

HPA

ENSG00000169439-SDC2

GeneCards

P34741

Ensembl

ENSP00000307046, ENST00000302190, ENSG00000169439

PRO

P34741

Pharos - Targets

P34741

HMDB Protein

HMDBP10737

PDB

6ITH

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) SDC2 [Golgi lumen] (R-HSA-2054101) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.655	4
UniProt:P18827 SDC1	20	SDC1 [plasma membrane] (R-HSA-174758) SDC1 [lysosomal lumen] (R-HSA-2090025) HS(6)-SDC1 [lysosomal lumen] (R-HSA-2090082) HS(1)-SDC1 [Golgi lumen] (R-HSA-2076321) HS(2)-SDC1 [Golgi lumen] (R-HSA-2076309) HS(3)-SDC1 [Golgi lumen] (R-HSA-2076444) HS(4)-SDC1 [Golgi lumen] (R-HSA-2076593) HS(6)-SDC1 [Golgi lumen] (R-HSA-2076520) HS(5)-SDC1 [Golgi lumen] (R-HSA-2076290) Heparan-SDC1 [Golgi lumen] (R-HSA-2076561) Heparan(1)-SDC1 [Golgi lumen] (R-HSA-2076349) Heparan(2)-SDC1 [Golgi lumen] (R-HSA-2076558) Heparan(4)-SDC1 [Golgi lumen] (R-HSA-2076339) Heparan(3)-SDC1 [Golgi lumen] (R-HSA-2076314) SDC1 [Golgi lumen] (R-HSA-2054105) XylS-SDC1 [Golgi lumen] (R-HSA-2064146) Gal-Xyl-SDC1 [Golgi lumen] (R-HSA-2064148) HS(4)-SDC1 [plasma membrane] (R-HSA-2076693) HS(6)-SDC1 [plasma membrane] (R-HSA-2076652) HS(2)-SDC1 [plasma membrane] (R-HSA-2076666)	0.59	3
UniProt:P31431 SDC4	20	SDC4 [lysosomal lumen] (R-HSA-2090041) HS(6)-SDC4 [lysosomal lumen] (R-HSA-2090058) HS(1)-SDC4 [Golgi lumen] (R-HSA-2076434) HS(2)-SDC4 [Golgi lumen] (R-HSA-2076411) HS(3)-SDC4 [Golgi lumen] (R-HSA-2076418) HS(4)-SDC4 [Golgi lumen] (R-HSA-2076407) HS(6)-SDC4 [Golgi lumen] (R-HSA-2076330) HS(5)-SDC4 [Golgi lumen] (R-HSA-2076510) Heparan-SDC4 [Golgi lumen] (R-HSA-2076374) Heparan(1)-SDC4 [Golgi lumen] (R-HSA-2076394) Heparan(2)-SDC4 [Golgi lumen] (R-HSA-2076446) Heparan(4)-SDC4 [Golgi lumen] (R-HSA-2076613) Heparan(3)-SDC4 [Golgi lumen] (R-HSA-2076460) SDC4 [Golgi lumen] (R-HSA-2054111) XylS-SDC4 [Golgi lumen] (R-HSA-2064195) HS(4)-SDC4 [plasma membrane] (R-HSA-2076670) HS(6)-SDC4 [plasma membrane] (R-HSA-2076633) HS(2)-SDC4 [plasma membrane] (R-HSA-2076694) HS(1)-SDC4 [plasma membrane] (R-HSA-2076653) HS(3)-SDC4 [plasma membrane] (R-HSA-2076674)	0.59	4
UniProt:P41271-2 NBL1			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:P28799-2 GRN			0.556	3
UniProt:Q13387-4 MAPK8IP2			0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312)	0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:O15354 GPR37	1	GPR37 [plasma membrane] (R-HSA-5333623)	0.556	3
UniProt:O60784-2 TOM1			0.556	3
IntAct:EBI-25834291 CCSB			0.556	3
UniProt:Q12797-6 ASPH			0.556	5
UniProt:Q63HN8 RNF213	3	RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9715284) RNF213(1-1172)-ALK(1058-1620) fusion [cytosol] (R-HSA-9715291) RNF213 [cytosol] (R-HSA-9635613)	0.527	2
UniProt:Q14592 ZNF460	1	ZNF460 [nucleoplasm] (R-HSA-1027424)	0.527	2
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	2
UniProt:Q9Y5Q9 GTF3C3	1	GTF3C3 [nucleoplasm] (R-HSA-83691)	0.527	2
UniProt:Q9UKD1 GMEB2			0.527	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	3
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.527	2
UniProt:Q6AI08 HEAT6			0.527	2
UniProt:P55084 HADHB	1	HADHB [mitochondrial inner membrane] (R-HSA-77266)	0.527	3
UniProt:Q8N441 FGFRL1	1	FGFRL1 [plasma membrane] (R-HSA-197650)	0.527	3
UniProt:Q99985 SEM3C			0.527	3
UniProt:Q8NCB2 CAMKV			0.527	2
UniProt:O60645 EXOC3	2	EXOC3 [secretory granule membrane] (R-HSA-2872286) EXOC3 [cytosol] (R-HSA-5623379)	0.527	2
UniProt:Q8WV41 SNX33			0.527	2
UniProt:P32249 GPR183	1	GPR183 [plasma membrane] (R-HSA-8851676)	0.527	3
UniProt:P0C0S8 H2AC11	11	K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) HIST1H2AG [nucleoplasm] (R-HSA-212084) Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311)	0.527	2
UniProt:Q6ZS30 NBEL1			0.527	2
UniProt:Q99584 S10AD			0.527	2
UniProt:Q9Y4F1 FARP1	1	FARP1 [cytosol] (R-HSA-9679578)	0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	2
UniProt:Q9ULK5 VANGL2	2	VANGL2 [plasma membrane] (R-HSA-3965373) pS5,S82,S84-VANGL2 [plasma membrane] (R-HSA-4551547)	0.527	2
UniProt:Q8IXQ5 KLHL7			0.527	3
UniProt:Q96B77 TMEM186	1	TMEM186 [mitochondrial inner membrane] (R-HSA-9708009)	0.527	2
UniProt:Q96QE5 TEFM			0.527	2
UniProt:P17152 TMEM11	1	TMEM11 [mitochondrial inner membrane] (R-HSA-8949578)	0.527	2
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) FGFR2 K660M [plasma membrane] (R-HSA-1637902) FGFR2 K660E [plasma membrane] (R-HSA-1637900) FGFR2 S267P [plasma membrane] (R-HSA-1637920) FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-1637908) FGFR2 W290C [plasma membrane] (R-HSA-1637929) p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853134) p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853146)	0.527	2
UniProt:Q8WY07 SLC7A3	1	SLC7A3 [plasma membrane] (R-HSA-375779)	0.527	2
UniProt:Q13268 DHRS2			0.527	3
UniProt:Q8IWU6 SULF1			0.527	2

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