Reactome | XPC [nucleoplasm]

XPC [nucleoplasm]

Stable Identifier

R-HSA-67441

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

XPC protein, DNA-repair protein complementing XP-C cells (Xeroderma pigmentosum group C complementing protein) (P125), xeroderma pigmentosum, complementation group C, DNA-repair protein complementing XP-C cells, Xeroderma pigmentosum group C complementing protein, p125

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - SUMOylation (Homo sapiens)
    - SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
      - SUMOylation of DNA damage response and repair proteins (Homo sapiens)
        
        SUMOylation of XPC with SUMO1 (Homo sapiens)
        
        XPC [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01831 XPC

Gene Names

XPC, XPCC

Chain

initiator methionine:1, chain:2-940

Reference Genes

BioGPS Gene:7508 XPC

COSMIC (genes):XPC XPC

CTD Gene:7508 XPC

dbSNP Gene:7508 XPC

ENSEMBL:ENSG00000154767 XPC

HGNC:12816 XPC

KEGG:hsa:7508 XPC

Monarch:7508 XPC

NCBI Gene:7508 XPC

OMIM:613208 XPC

UCSC:Q01831 XPC

Reference Transcript

RefSeq:NM_004628.4 XPC

Participates

as an input of

as a component of

XPC:RAD23:CETN2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub,SUMO-XPC [nucleoplasm]

Ub,SUMO,K63polyUb-XPC [nucleoplasm]

Ub-XPC [nucleoplasm]

monoSUMO1-K655-XPC [nucleoplasm]

Inferred To

RAD4 [nucleoplasm] (Saccharomyces cerevisiae)

rhp41 [nucleoplasm] (Schizosaccharomyces pombe)

XPC [nucleoplasm] (Bos taurus)

XPC [nucleoplasm] (Canis familiaris)

XPC [nucleoplasm] (Gallus gallus)

XPC [nucleoplasm] (Plasmodium falciparum)

XPC [nucleoplasm] (Sus scrofa)

rad4 [nucleoplasm] (Dictyostelium discoideum)

xpc-1 [nucleoplasm] (Caenorhabditis elegans)

Xpc [nucleoplasm] (Drosophila melanogaster)

Xpc [nucleoplasm] (Mus musculus)

Xpc [nucleoplasm] (Rattus norvegicus)

xpc [nucleoplasm] (Danio rerio)

xpc [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_004619.3

OpenTargets

ENSG00000154767

ENSEMBL

ENST00000285021, ENST00000476581, ENSG00000154767, ENSP00000285021, ENSP00000424548

GeneCards

XPC

HPA

ENSG00000154767-XPC

PRO

Q01831

Pharos - Targets

Q01831

GlyGen

Q01831

Orphanet

XPC

HMDB Protein

HMDBP12797

PDB

8EBT, 2RVB, 8EBS, 2GGM, 8EBY, 2A4J, 2OBH, 8EBW, 8EBV, 8EBX, 8EBU

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54727 RAD23B	2	RAD23B [cytosol] (R-HSA-8850589) RAD23B [nucleoplasm] (R-HSA-62590)	0.903	15
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.901	14
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.725	7
UniProt:O15182 CETN3			0.725	8
UniProt:P09874 PARP1	4	PARP1 [nucleoplasm] (R-HSA-201568) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) monoSUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) polySUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617)	0.725	5
UniProt:P13288 KR2			0.645	9
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.643	4
UniProt:Q12798 CETN1	7	PolyUb-Misfolded CETN1 [late endosome lumen] (R-HSA-9659982) CETN1 [cilium] (R-HSA-9639700) Misfolded CETN1 [cilium] (R-HSA-9639714) Misfolded CETN1 [cytosol] (R-HSA-9640113) Ub-Misfolded CETN1 [cytosol] (R-HSA-9641110) PolyUb-Misfolded CETN1 [cytosol] (R-HSA-9641126) PolyUb-Misfolded CETN1 [lysosomal lumen] (R-HSA-9659990)	0.643	6
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [cytosol] (R-HSA-3134813)	0.643	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.643	4
UniProt:Q9NRW3 APOBEC3C	1	APOBEC3C [nucleoplasm] (R-HSA-8874997)	0.643	3
UniProt:P19447 ERCC3	1	ERCC3 [nucleoplasm] (R-HSA-67439)	0.59	3
UniProt:P32780 GTF2H1	1	GTF2H1 [nucleoplasm] (R-HSA-65912)	0.59	3
UniProt:Q9R1K9	3	Cetn2 [nucleoplasm] (R-MMU-4570486) Cetn2 [nucleoplasm] (R-MMU-4570490) Cetn2 [cytosol] (R-MMU-380298)	0.564	2
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.527	3
UniProt:P06746 POLB	2	POLB [nucleoplasm] (R-HSA-53845) PolyUb-POLB [nucleoplasm] (R-HSA-6783152)	0.527	2
UniProt:P23527 H2BC17	9	Ub-HIST1H2BO [nucleoplasm] (R-HSA-6782549) AcK-HIST1H2BO [nucleoplasm] (R-HSA-4549268) HIST1H2BO [extracellular region] (R-HSA-977557) Ub-121-HIST1H2BO [nucleoplasm] (R-HSA-3364033) AcK13-HIST1H2BO [nucleoplasm] (R-HSA-4568712) AcK21-HIST1H2BO [nucleoplasm] (R-HSA-4568713) AcK16-HIST1H2BO [nucleoplasm] (R-HSA-4568681) AcK6-HIST1H2BO [nucleoplasm] (R-HSA-4568708) HIST1H2BO [nucleoplasm] (R-HSA-181910)	0.527	3
UniProt:P0C0S5 H2AZ1	1	H2AFZ [extracellular region] (R-HSA-977575)	0.527	4
UniProt:O75367 H2AY			0.527	4
UniProt:Q9P0M6 H2AW			0.527	3
UniProt:P0C0S8 H2AC11	11	Ack-HIST1H2AG [nucleoplasm] (R-HSA-4551311) HIST1H2AG [nucleoplasm] (R-HSA-212084) MeR12-HIST1H2AG [nucleoplasm] (R-HSA-5229206) Me2aR12-HIST1H2AG [nucleoplasm] (R-HSA-5229305) MeR4-HIST1H2AG [nucleoplasm] (R-HSA-5244623) Me2aR4-HIST1H2AG [nucleoplasm] (R-HSA-5244587) MeR30-HIST1H2AG [nucleoplasm] (R-HSA-5244560) Me2aR30-HIST1H2AG [nucleoplasm] (R-HSA-5244582) Ack6-HIST1H2AG [nucleoplasm] (R-HSA-4568595) Ub-HIST1H2AG [nucleoplasm] (R-HSA-6782508) K63polyUb-HIST1H2AG [nucleoplasm] (R-HSA-6783237)	0.527	4
UniProt:Q8IW19 APLF			0.527	2
UniProt:P58876 H2BC5	9	Ub-HIST1H2BD [nucleoplasm] (R-HSA-6782546) AcK-HIST1H2BD [nucleoplasm] (R-HSA-4549255) HIST1H2BD [extracellular region] (R-HSA-977561) Ub-121-HIST1H2BD [nucleoplasm] (R-HSA-3364025) AcK16-HIST1H2BD [nucleoplasm] (R-HSA-4568633) AcK6-HIST1H2BD [nucleoplasm] (R-HSA-4568642) AcK21-HIST1H2BD [nucleoplasm] (R-HSA-4568627) AcK13-HIST1H2BD [nucleoplasm] (R-HSA-4568645) HIST1H2BD [nucleoplasm] (R-HSA-181912)	0.527	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) SDC2 [Golgi lumen] (R-HSA-2054101) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607)	0.527	2
UniProt:Q9BPZ2 SPI2B			0.527	2
UniProt:P62906 RPL10A	1	RPL10A [cytosol] (R-HSA-72404)	0.527	3
UniProt:Q86UY6 NAA40			0.527	2
UniProt:Q13156 RPA4	1	RPA4 [nucleoplasm] (R-HSA-68566)	0.527	3
UniProt:Q96A08 H2BC1	9	HIST1H2BA [nucleoplasm] (R-HSA-181916) AcK22-HIST1H2BA [nucleoplasm] (R-HSA-4568647) AcK17-HIST1H2BA [nucleoplasm] (R-HSA-4568631) AcK14-HIST1H2BA [nucleoplasm] (R-HSA-4568615) AcK7-HIST1H2BA [nucleoplasm] (R-HSA-4568624) Ub-122-HIST1H2BA [nucleoplasm] (R-HSA-3364020) HIST1H2BA [extracellular region] (R-HSA-977582) AcK-HIST1H2BA [nucleoplasm] (R-HSA-4549263) Ub-HIST1H2BA [nucleoplasm] (R-HSA-6782561)	0.527	3
UniProt:Q9BQ69 MACD1			0.527	2
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [secretory granule lumen] (R-HSA-6801319) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290)	0.527	2
UniProt:P50914 RPL14	1	RPL14 [cytosol] (R-HSA-72414)	0.527	3
UniProt:P16104 H2AX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:P68431 H3C1	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135) MeK80-HIST1H3A [nucleoplasm] (R-HSA-5649791)	0.483	2

Cite Us!