ESRP1-RAF1 fusion [cytosol]

Stable Identifier
R-HSA-6802312
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
20526349 Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

Shankar, S, Siddiqui, J, Kuefer, R, Chen, YB, Greenson, JK, Lafargue, CJ, Ramnarayanan, K, Han, B, Palanisamy, N, Demichelis, F, Esgueva, R, Dhanasekaran, SM, Giordano, TJ, Fullen, DR, Pflueger, D, Moeller, P, Rubin, MA, Maher, CA, Cao, Q, Cao, X, Ateeq, B, Banerjee, S, Bismar, TA, Tomlins, SA, Varambally, S, Kumar-Sinha, C, Chinnaiyan, AM, Johnson, TM, Suleman, K, Tan, P, Kalyana-Sundaram, S

Nat. Med. 2010
External Reference Information
External Reference
Gene Names
ESRP1, RBM35A
Chain
chain:1-681
Other Identifiers
0000070402
11723543_a_at
11723544_a_at
17070949
219121_s_at
225846_at
3107549
3107550
3107552
3107554
3107555
3107563
3107564
3107565
3107566
3107567
3107568
3107570
3107571
3107578
3107585
3107586
3107587
3107590
3107593
3107594
3631959
50391_at
54845
8147351
82072_at
A_14_P135791
A_23_P259127
GE55386
GO:0003674
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0006397
GO:0007165
GO:0008150
GO:0008380
GO:0008543
GO:0016604
GO:0030154
GO:0032991
GO:0034641
GO:0042669
GO:0043226
GO:0043484
GO:0048856
GO:1990904
HMNXSV003048506
HMNXSV003056263
Hs.24743.1.A1_3p_at
ILMN_1749180
PH_hs_0002178
TC08000575.hg
g8923166_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 227 to 648 at 607 from UniProt:P04049 RAF1
Coordinate
607
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
prostate cancer DOID:10283 NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Interactors (36)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P54253 ATX1      0.805 12
 UniProt:P22607 FGFR3  20 0.556 3
 UniProt:Q6ZRY4 RBPS2      0.556 3
 UniProt:Q9Y3C5 RNF11      0.556 3
 UniProt:P13637 ATP1A3  1 0.556 3
 UniProt:Q9Y649 Q9Y649      0.556 3
 IntAct:EBI-25857482 CCSB      0.556 3
 UniProt:Q96G42 KLD7B      0.556 3
 UniProt:Q15038 DAZP2      0.556 3
 UniProt:O60333-2 KIF1B      0.556 3
 UniProt:A0A140G945 CRYA2      0.556 3
 UniProt:Q3LI72 KRTAP19-5  1 0.556 3
 UniProt:Q9UMX0 UBQLN1  1 0.556 3
 UniProt:Q03989 ARI5A      0.556 3
 UniProt:Q13393 PLD1  4 0.556 3
 UniProt:P86480 PR20D      0.556 3
 UniProt:Q86V38 Q86V38      0.556 3
 UniProt:P28329-3 P283293      0.556 3
 UniProt:P46379-2 BAG6      0.556 3
 UniProt:P48643 CCT5  1 0.556 3
 UniProt:O14645 IDLC      0.556 3
 UniProt:O14901 KLF11      0.556 3
 UniProt:Q92876 KLK6      0.556 3
 UniProt:Q14203-5 DCTN1      0.556 3
 IntAct:EBI-25847655 CCSB      0.556 3
 UniProt:Q13148 TADBP      0.556 6
 UniProt:P02766 TTR  2 0.556 3
 UniProt:O76024 WFS1  3 0.556 3
 UniProt:Q8TDS5 OXER1  1 0.556 3
 UniProt:P04792 HSPB1  3 0.556 3
 UniProt:P00488 F13A1  4 0.556 3
 UniProt:P16284 PECAM1  4 0.556 3
 UniProt:P08670 VIM  11 0.556 3
 UniProt:Q71SY5 MED25  1 0.556 3
 UniProt:P34741 SDC2  20 0.556 3
 UniProt:P10809 HSPD1  6 0.556 3
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