Reactome | TMEM186 [mitochondrial inner membrane]

TMEM186 [mitochondrial inner membrane]

Stable Identifier

R-HSA-9708009

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Transmembrane protein 186, TM186_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96B77 TMEM186

Gene Names

TMEM186, C16orf51

Chain

chain:1-213

Reference Genes

BioGPS Gene:25880 TMEM186

COSMIC (genes):TMEM186 TMEM186

CTD Gene:25880 TMEM186

dbSNP Gene:25880 TMEM186

ENSEMBL:ENSG00000184857 TMEM186

HGNC:24530 TMEM186

KEGG:hsa:25880 TMEM186

Monarch:25880 TMEM186

NCBI Gene:25880 TMEM186

OMIM:620433 TMEM186

UCSC:Q96B77 TMEM186

Reference Transcript

RefSeq:NM_015421.3 TMEM186

Other Identifiers

11721544_at

16823746

204676_PM_at

204676_at

25880

3679504

3679505

3679506

3679507

3679508

3679509

3679510

40341_at

64310_at

7999317

A_23_P26687

GE56330

GO:0005515

GO:0005739

GO:0005743

GO:0032981

GO:0043226

GO:0065003

HMNXSV003033577

ILMN_2230998

PH_hs_0004126

TC16000850.hg

g7661617_3p_at

Participates

as a component of

TMEM186:MT-ND3 [mitochondrial inner membrane] (Homo sapiens)

Inferred To

Dmel\CG4627 [mitochondrial inner membrane] (Drosophila melanogaster)

TMEM186 [mitochondrial inner membrane] (Bos taurus)

TMEM186 [mitochondrial inner membrane] (Canis familiaris)

TMEM186 [mitochondrial inner membrane] (Gallus gallus)

TMEM186 [mitochondrial inner membrane] (Sus scrofa)

Ghost homologue of TMEM186 [mitochondrial inner membrane] (Caenorhabditis elegans)

Tmem186 [mitochondrial inner membrane] (Mus musculus)

Tmem186 [mitochondrial inner membrane] (Rattus norvegicus)

tmem186 [mitochondrial inner membrane] (Danio rerio)

tmem186 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000333050, ENSP00000331640

OpenTargets

ENSG00000184857

HPA

ENSG00000184857-TMEM186

PRO

Q96B77

Pharos - Targets

Q96B77

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q71RS6 SLC24A5	3	SLC24A5 W591* [trans-Golgi network membrane] (R-HSA-5626353) SLC24A5 L454Ffs*33 [trans-Golgi network membrane] (R-HSA-5626326) SLC24A5 [trans-Golgi network membrane] (R-HSA-425660)	0.527	2
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.527	2
UniProt:Q9H8X2 IPPK	2	IPPK [cytosol] (R-HSA-1604598) IPPK [nucleoplasm] (R-HSA-2023949)	0.527	2
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.527	2