Reactome | ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]

ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]

Stable Identifier

R-HSA-6802523

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
20526349	Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma Shankar, S, Siddiqui, J, Kuefer, R, Chen, YB, Greenson, JK, Lafargue, CJ, Ramnarayanan, K, Han, B, Palanisamy, N, Demichelis, F, Esgueva, R, Dhanasekaran, SM, Giordano, TJ, Fullen, DR, Pflueger, D, Moeller, P, Rubin, MA, Maher, CA, Cao, Q, Cao, X, Ateeq, B, Banerjee, S, Bismar, TA, Tomlins, SA, Varambally, S, Kumar-Sinha, C, Chinnaiyan, AM, Johnson, TM, Suleman, K, Tan, P, Kalyana-Sundaram, S	Nat. Med.	2010

External Reference Information

External Reference

UniProt:Q6NXG1 ESRP1

Gene Names

ESRP1, RBM35A

Chain

chain:1-681

Reference Genes

BioGPS Gene:54845 ESRP1

COSMIC (genes):ESRP1 ESRP1

CTD Gene:54845 ESRP1

dbSNP Gene:54845 ESRP1

ENSEMBL:ENSG00000104413.18 ESRP1

HGNC:25966 ESRP1

KEGG Gene (Homo sapiens):54845 ESRP1

Monarch:54845 ESRP1

NCBI Gene:54845 ESRP1

OMIM:612959 ESRP1

UCSC:Q6NXG1 ESRP1

Reference Transcript

Other Identifiers

0000070402

11723543_a_at

11723544_a_at

17070949

219121_PM_s_at

219121_s_at

225846_PM_at

225846_at

3107549

3107550

3107552

3107554

3107555

3107563

3107564

3107565

3107566

3107567

3107568

3107570

3107571

3107578

3107585

3107586

3107587

3107590

3107593

3107594

3631959

50391_at

54845

8147351

82072_at

A_14_P135791

A_23_P259127

GE55386

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0006397

GO:0008380

GO:0016071

GO:0016604

GO:0030154

GO:0032991

GO:0042669

GO:0043226

GO:0043484

GO:0048856

GO:1990904

HMNXSV003048506

HMNXSV003056263

Hs.24743.1.A1_3p_at

ILMN_1749180

PH_hs_0002178

TC08000575.hg

g8923166_3p_a_at

Participates

as a component of

p-ESRP1-RAF1 fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ESRP1 [nucleoplasm]

ESRP1(1-606)-RAF1(227-648) fusion [cytosol]

Modified Residues

Name

Insertion of residues 227 to 648 at 607 from UniProt:P04049 RAF1

Coordinate

607

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 338

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 491

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
prostate cancer	DOID:10283	NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm

Cross References

RefSeq

NP_060167.2, NP_001116299.1, NP_001116297.1, XP_005251048.1, NP_001030087.2, NP_001116298.1

OpenTargets

ENSG00000104413

GeneCards

Q6NXG1

HPA

ENSG00000104413-ESRP1

Ensembl

ENSG00000104413, ENST00000423620, ENSP00000351168, ENSP00000494213, ENST00000433389, ENST00000358397, ENSP00000407349, ENST00000646773, ENSP00000405738

PRO

Q6NXG1

Pharos - Targets

Q6NXG1

Orphanet

28885

PDB

2DHA, 2RVJ

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.805	12
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P13637 ATP1A3	1	ATP1A3 [plasma membrane] (R-HSA-936803)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
IntAct:EBI-25857482 CCSB			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631)	0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q13393 PLD1	4	PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:P00488 F13A1	4	factor XIIIa A chain [extracellular region] (R-HSA-140788) factor XIII A chain [extracellular region] (R-HSA-140600) factor XIII A chain activation peptide [extracellular region] (R-HSA-140790) F13A1(1-731) [platelet alpha granule lumen] (R-HSA-349759)	0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3

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