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RNF213 [cytosol]
Stable Identifier
R-HSA-9635613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
fullName evidence="34"E3 ubiquitin-protein ligase RNF213 ecNumber evidence="16"2.3.2.27/ecNumber ecNumber evidence="16"3.6.4.-/ecNumber, RN213_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Infection with Mycobacterium tuberculosis (Homo sapiens)
Response of Mtb to phagocytosis (Homo sapiens)
Suppression of apoptosis (Homo sapiens)
Rv3655c binds RNF213 (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Rv3655c:RFN213 [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF213 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q63HN8 RNF213
Gene Names
RNF213, ALO17, C17orf27, KIAA1554, KIAA1618, MYSTR
Chain
chain:1-5207
Reference Genes
BioGPS Gene:57674 RNF213
COSMIC (genes):RNF213 RNF213
CTD Gene:57674 RNF213
dbSNP Gene:57674 RNF213
ENSEMBL:ENSG00000173821.20 RNF213
HGNC:14539 RNF213
KEGG Gene (Homo sapiens):57674 RNF213
Monarch:57674 RNF213
NCBI Gene:57674 RNF213
OMIM:613768 RNF213
UCSC:Q63HN8 RNF213
Reference Transcript
RefSeq:NM_020954.3 RNF213
RefSeq:NM_001256071.2 RNF213
Other Identifiers
11731751_at
11731752_at
232155_PM_at
232155_at
241347_PM_at
241347_at
3737275
3737277
3737278
3737283
3737287
3737288
3737289
3737290
3737291
3737292
3737293
3737294
3737295
3737297
3737298
3737299
3737300
3737301
3737302
3737304
3737305
3737306
3737307
3737308
3737309
57674
68047_at
8010426
81774_at
A_33_P3219591
GE63147
GO:0000166
GO:0001525
GO:0002040
GO:0002376
GO:0003824
GO:0004842
GO:0005524
GO:0005634
GO:0005730
GO:0005737
GO:0005811
GO:0005829
GO:0006511
GO:0006629
GO:0006914
GO:0008152
GO:0016020
GO:0016567
GO:0016740
GO:0016787
GO:0016887
GO:0019216
GO:0023052
GO:0030163
GO:0036211
GO:0042742
GO:0043226
GO:0046872
GO:0048856
GO:0051865
GO:0061630
GO:0070534
GO:0098542
GO:0098792
GO:0120323
GO:0140042
GO:0140096
GO:0140657
GO:2000051
HMNXSV003000734
Hs.124135.0.S1_3p_at
ILMN_1674891
ILMN_1731203
ILMN_2289093
PH_hs_0040297
Participates
as a component of
Rv3655c:RFN213 [cytosol] (Homo sapiens)
as an input of
Rv3655c binds RNF213 (Homo sapiens)
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
RNF213(1-1172)-p-7Y ALK(1058-1620) fusion [cytosol]
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
Inferred To
Rnf213 [cytosol]
(Rattus norvegicus)
LOC100496402 [cytosol]
(Xenopus tropicalis)
Homologues of RNF213 [cytosol]
(Dictyostelium discoideum)
LOC509283 [cytosol]
(Bos taurus)
RNF213 [cytosol]
(Canis familiaris)
RNF213 [cytosol]
(Danio rerio)
RNF213 [cytosol]
(Dictyostelium discoideum)
RNF213 [cytosol]
(Gallus gallus)
RNF213 [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001243000.2
,
NP_066005.2
OpenTargets
ENSG00000173821
HPA
ENSG00000173821-RNF213
GeneCards
Q63HN8
Ensembl
ENST00000319921
,
ENSP00000324392
,
ENSG00000173821
PRO
Q63HN8
Pharos - Targets
Q63HN8
Orphanet
19846
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P18031 PTPN1
2
PTPN1 [cytosol]
(R-HSA-210625)
PTPN1 [endosome membrane]
(R-HSA-9815895)
0.527
2
UniProt:P05919 vpu
6
VPU (P05919) protein [extracellular region]
(R-HIV-175522)
VPU (P05919) protein [cytosol]
(R-HIV-173223)
VPU (P05919) protein [nucleoplasm]
(R-HIV-175200)
VPU (P05919) [endoplasmic reticulum membrane]
(R-HIV-180550)
VPU (P05919) [Golgi membrane]
(R-HIV-3149439)
VPU (P05919) [plasma membrane]
(R-HIV-3149423)
0.462
2
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