As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. PTK2 (protein-tyrosine kinase 2, also known as Focal adhesion kinase 1; FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. PTK2 has been implicated in controlling cell motility and transmitting a cell survival signal from ECM. PTK2 is recruited to sites of integrin clustering by directly binding to integrin associated c-Src.
Schaller, MD
Mitra, SK, Schlaepfer, DD
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