Reactome | PTK2 binds activated MET

PTK2 binds activated MET

Stable Identifier

R-HSA-8874079

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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PTK2 (FAK1) protein tyrosine kinase binds to activated MET receptor through the interaction of the FERM domain of PTK2 and phosphorylated tyrosine residues p-Y1349 and p-Y1356 of MET (Chen and Chen 2006). HGF-mediated activation of PTK2 requires interaction of integrins with the extracellular matrix components: collagen, laminin and fibronectin. HGF-mediated activation of MET causes extensive formation of new focal adhesions that contain PTK2 (Beviglia and Kramer 1999). Paxillin may also be involved in this interaction (Parr et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
10521801	HGF induces FAK activation and integrin-mediated adhesion in MTLn3 breast carcinoma cells Kramer, RH, Beviglia, L	Int. J. Cancer	1999
16782899	Direct interaction of focal adhesion kinase (FAK) with Met is required for FAK to promote hepatocyte growth factor-induced cell invasion Chen, HC, Chen, SY	Mol. Cell. Biol.	2006