PTK2 (FAK1) protein tyrosine kinase binds to activated MET receptor through the interaction of the FERM domain of PTK2 and phosphorylated tyrosine residues p-Y1349 and p-Y1356 of MET (Chen and Chen 2006). HGF-mediated activation of PTK2 requires interaction of integrins with the extracellular matrix components: collagen, laminin and fibronectin. HGF-mediated activation of MET causes extensive formation of new focal adhesions that contain PTK2 (Beviglia and Kramer 1999). Paxillin may also be involved in this interaction (Parr et al. 2001).