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PTK2 [cytosol]
Stable Identifier
R-RNO-201621
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
O35346
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to mechanical stimuli (Rattus norvegicus)
Response of endothelial cells to shear stress (Rattus norvegicus)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Rattus norvegicus)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Src phosphorylate WASP,N-WASP (Rattus norvegicus)
Src-kinases [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Apoptotic execution phase (Rattus norvegicus)
Apoptotic cleavage of cellular proteins (Rattus norvegicus)
Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
PTK2 autophosphorylates downstream of EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 binds activated EGFR (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET promotes cell motility (Rattus norvegicus)
MET activates PTK2 signaling (Rattus norvegicus)
PTK2 autophosphorylates (Rattus norvegicus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 binds activated MET (Rattus norvegicus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
PTK2 autophosphorylates (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases Activate WASPs and WAVEs (Rattus norvegicus)
Src phosphorylate WASP,N-WASP (Rattus norvegicus)
Src-kinases [cytosol] (Rattus norvegicus)
PTK2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O35346 Ptk2
Gene Names
Ptk2, Fak, Fak1
Chain
initiator methionine:1, chain:2-1055
Reference Genes
BioGPS Gene:25614 Ptk2
KEGG:rno:25614 Ptk2
Monarch:25614 Ptk2
NCBI Gene:25614 Ptk2
UCSC:O35346 Ptk2
Reference Transcript
RefSeq:NM_013081.2 Ptk2
Participates
as an input of
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Rattus norvegicus)
PTK2 binds activated MET (Rattus norvegicus)
PTK2 binds activated EGFR (Rattus norvegicus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
Caspase-mediated cleavage of FADK 1 (Rattus norvegicus)
as a component of
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Rattus norvegicus)
HGF:p-4Y-MET dimer:PTK2 [plasma membrane] (Rattus norvegicus)
EGF-like ligands:p-6Y EGFR:PTK2 [plasma membrane] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:p-SHB:PTK2 [plasma membrane] (Rattus norvegicus)
as a member of
Src-kinases [cytosol] (Rattus norvegicus)
Other forms of this molecule
FAK1_RAT [cytosol]
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
phospho-p-Y194,Y397-PTK2 [cytosol]
phospho-pY-PTK2 [cytosol]
phospho-p-5Y-PTK2 [cytosol]
phospho-p-5Y,S732-PTK2 [cytosol]
phospho-p-6Y,S732-PTK2 [cytosol]
PTK2(773-1052) [cytosol]
PTK2(1-772) [cytosol]
phospho-p-Y397-PTK2 [cytosol]
phospho-p-6Y-PTK2 [cytosol]
Inferred From
PTK2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_037213.1
ZINC - Substances
FAK1_RAT
ZINC target
O35346
PRO
O35346
RGD
3443
ZINC - Predictions - Purchasable
FAK1_RAT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35346 Ptk2
12
FAK1_RAT [cytosol]
(R-RNO-548922)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-RNO-8874613)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-RNO-8874600)
phospho-pY-PTK2 [cytosol]
(R-RNO-9632393)
phospho-p-5Y-PTK2 [cytosol]
(R-RNO-5218711)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-RNO-5229006)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-RNO-5218694)
PTK2(773-1052) [cytosol]
(R-RNO-202829)
PTK2(1-772) [cytosol]
(R-RNO-202827)
PTK2 [cytosol]
(R-RNO-201621)
phospho-p-Y397-PTK2 [cytosol]
(R-RNO-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-RNO-354128)
0.721
12
UniProt:Q6P6T5
3
Ocln [plasma membrane]
(R-RNO-351854)
Ocln [plasma membrane]
(R-RNO-351873)
Ocln [plasma membrane]
(R-RNO-351846)
0.589
2
UniProt:A0A8I5ZZ93 A0A8I5ZZ93
0.463
3
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