PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2

Stable Identifier
R-HSA-4420083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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SHB binds focal adhesion kinase 1 (FAK1; also known as PTK2) via its PTB domain in a phosphotyrosine-dependent manner. This regulates FAK1 phosphorylation, leading to Src dependent enhanced cell spreading (Holmqvist et al. 2003). During vascular development, FAK1 is involved in the control of endothelial cell migration (Holmquist et al. 2004), vascular permeability (Chen et al. 2012) and tube formation (Bohnsack & Hirshi, 2003).

Literature References
PubMed ID Title Journal Year
15026417 The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration

Holmqvist, K, Cross, MJ, Rolny, C, Hägerkvist, R, Rahimi, N, Matsumoto, T, Claesson-Welsh, L, Welsh, M

J. Biol. Chem. 2004
9182576 Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells

Abedi, H, Zachary, I

J. Biol. Chem. 1997
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