PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2

Stable Identifier
R-HSA-4420083
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2
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SHB binds focal adhesion kinase 1 (FAK1; also known as PTK2) via its PTB domain in a phosphotyrosine-dependent manner. This regulates FAK1 phosphorylation, leading to Src dependent enhanced cell spreading (Holmqvist et al. 2003). During vascular development, FAK1 is involved in the control of endothelial cell migration (Holmquist et al. 2004), vascular permeability (Chen et al. 2012) and tube formation (Bohnsack & Hirshi, 2003).

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Orthologous Events
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Bos taurus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Canis familiaris)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Gallus gallus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Mus musculus)
PTK2 binds p-S-SHB and is recruited to p-6Y-VEGFR2 (Rattus norvegicus)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Ballmer-Hofer, K  (2014-05-12)
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Created
Garapati, P V  (2013-08-30)
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