Reactome | PTPN23 [nucleoplasm]

PTPN23 [nucleoplasm]

Stable Identifier

R-HSA-9008924

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-37 signaling (Homo sapiens)
        
        PTPNs gene transcription and translation (Homo sapiens)
        
        PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)
        
        PTPN23 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H3S7 PTPN23

Gene Names

PTPN23, KIAA1471

Chain

chain:1-1636

Reference Genes

BioGPS Gene:25930 PTPN23

COSMIC (genes):PTPN23 PTPN23

CTD Gene:25930 PTPN23

dbSNP Gene:25930 PTPN23

ENSEMBL:ENSG00000076201 PTPN23

ENSEMBL:ENSG00000076201.16 PTPN23

HGNC:14406 PTPN23

KEGG Gene (Homo sapiens):25930 PTPN23

Monarch:25930 PTPN23

NCBI Gene:25930 PTPN23

OMIM:606584 PTPN23

UCSC:Q9H3S7 PTPN23

Reference Transcript

Other Identifiers

11720389_a_at

11720390_a_at

11745293_x_at

16940362

223149_PM_s_at

223149_s_at

223150_PM_s_at

223150_s_at

25930

2621335

2621336

2621337

2621340

2621341

2621342

2621343

2621344

2621345

2621346

2621347

2621348

2621350

2621351

2621352

2621353

2621354

2621356

2621357

2621358

2621359

2621361

2621363

2621365

2621366

2621367

2621368

2621369

2621370

2621371

2621372

2621373

2621374

2621375

2621376

2621378

2621379

2621380

2621382

2621383

2621384

2621385

2621386

2621387

50431_at

62965_at

8079532

A_14_P127885

A_23_P212329

A_23_P69306

A_24_P328675

GE56431

GO:0003824

GO:0004721

GO:0004725

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005769

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0006470

GO:0006886

GO:0007155

GO:0010633

GO:0015031

GO:0016192

GO:0016311

GO:0016604

GO:0016787

GO:0016791

GO:0019901

GO:0023052

GO:0030030

GO:0030163

GO:0031410

GO:0032456

GO:0034330

GO:0036064

GO:0036211

GO:0042995

GO:0043162

GO:0043226

GO:0043231

GO:0043328

GO:0044782

GO:0045022

GO:0048870

GO:0060271

GO:0061357

GO:0070062

GO:0140096

GO:1903387

GO:1903393

GO:2000643

HMNXSV003028473

Hs.25524.0.S1_3p_a_at

ILMN_1654318

PH_hs_0002244

TC03000268.hg

g13491975_3p_a_at

Participates

as a member of

PTPNs2,4,5,6,7,9,11,12,13,14,18,20,23 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_056281.1, NP_001291411.1

OpenTargets

ENSG00000076201

GeneCards

Q9H3S7

HPA

ENSG00000076201-PTPN23

Ensembl

ENSP00000265562, ENSG00000076201, ENST00000265562

PRO

Q9H3S7

Pharos - Targets

Q9H3S7

Orphanet

29294

HMDB Protein

HMDBP11573

PDB

5MJY, 5MK1, 5MK3, 3RAU, 5MJZ, 5CRV, 5CRU, 5LM1, 5MK0, 5MK2, 5LM2

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.786	7
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.724	6
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.658	4
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.639	4
UniProt:O89100 Grap2	2	Grap2 [cytosol] (R-MMU-9680624) Grap2 [cytosol] (R-MMU-202367)	0.602	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q99962 SH3GL2	4	SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.508	2
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.499	2