PTK2 binds activated EGFR

Stable Identifier
R-HSA-9625482
Type
Reaction [binding]
Species
Homo sapiens
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PTK2 (also known as FAK, focal adhesion kinase) binds to the activated EGFR receptor as assessed by affinity chromatography and co-immunoprecipitation (Sieg et al, 2000; Thelemann et al, 2005; Liu et al, 2010). Stimulation of the EGFR pathway increases PTK2 phosphorylation at Y397, and FAK phosphorylation contributes to cell migration and tumorigenicity (Tamura et al, 1998; Gu et al, 1999; Sieg et al, 2000; Liu et al, 2010; reviewed in Zhu et al, 2018). PTK2-stimulated cell motility depends on integrins and is transduced through phosphorylated MAPK3 and MAPK1 (also known as ERK1 and ERK2) (Sieg et al, 2000; Thelemann et al, 2000; Liu et al, 2005).

Literature References
PubMed ID Title Journal Year
20650261 The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway

Liu, M, Yang, Y, Wang, C, Sun, L, Mei, C, Yao, W, Liu, Y, Shi, Y, Qiu, S, Fan, J, Cai, X, Zha, X

Arch. Biochem. Biophys. 2010
9616126 Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

Tamura, M, Gu, J, Matsumoto, K, Aota, S, Parsons, R, Yamada, KM

Science 1998
10427092 Shc and FAK differentially regulate cell motility and directionality modulated by PTEN

Gu, J, Tamura, M, Pankov, R, Danen, EH, Takino, T, Matsumoto, K, Yamada, KM

J. Cell Biol. 1999
15657067 Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells

Thelemann, A, Petti, F, Griffin, G, Iwata, K, Hunt, T, Settinari, T, Fenyo, D, Gibson, N, Haley, JD

Mol. Cell Proteomics 2005
10806474 FAK integrates growth-factor and integrin signals to promote cell migration

Sieg, DJ, Hauck, CR, Ilic, D, Klingbeil, CK, Schaefer, E, Damsky, CH, Schlaepfer, DD

Nat. Cell Biol. 2000
29738483 Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer

Zhu, X, Bao, Y, Guo, Y, Yang, W

Cancers (Basel) 2018
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