Reactome | PTK2 binds activated EGFR

PTK2 binds activated EGFR

Stable Identifier

R-HSA-9625482

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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PTK2 (also known as FAK, focal adhesion kinase) binds to the activated EGFR receptor as assessed by affinity chromatography and co-immunoprecipitation (Sieg et al, 2000; Thelemann et al, 2005; Liu et al, 2010). Stimulation of the EGFR pathway increases PTK2 phosphorylation at Y397, and FAK phosphorylation contributes to cell migration and tumorigenicity (Tamura et al, 1998; Gu et al, 1999; Sieg et al, 2000; Liu et al, 2010; reviewed in Zhu et al, 2018). PTK2-stimulated cell motility depends on integrins and is transduced through phosphorylated MAPK3 and MAPK1 (also known as ERK1 and ERK2) (Sieg et al, 2000; Thelemann et al, 2000; Liu et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
9616126	Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN Tamura, M, Gu, J, Matsumoto, K, Aota, S, Parsons, R, Yamada, KM	Science	1998
20650261	The effect of epidermal growth factor receptor variant III on glioma cell migration by stimulating ERK phosphorylation through the focal adhesion kinase signaling pathway Liu, M, Yang, Y, Wang, C, Sun, L, Mei, C, Yao, W, Liu, Y, Shi, Y, Qiu, S, Fan, J, Cai, X, Zha, X	Arch. Biochem. Biophys.	2010
10427092	Shc and FAK differentially regulate cell motility and directionality modulated by PTEN Gu, J, Tamura, M, Pankov, R, Danen, EH, Takino, T, Matsumoto, K, Yamada, KM	J. Cell Biol.	1999
15657067	Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells Thelemann, A, Petti, F, Griffin, G, Iwata, K, Hunt, T, Settinari, T, Fenyo, D, Gibson, N, Haley, JD	Mol. Cell Proteomics	2005
10806474	FAK integrates growth-factor and integrin signals to promote cell migration Sieg, DJ, Hauck, CR, Ilic, D, Klingbeil, CK, Schaefer, E, Damsky, CH, Schlaepfer, DD	Nat. Cell Biol.	2000
29738483	Proline-Rich Protein Tyrosine Kinase 2 in Inflammation and Cancer Zhu, X, Bao, Y, Guo, Y, Yang, W	Cancers (Basel)	2018